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1/ When the CAS enzyme does a double stranded break (DSB), it can be repaired by 2 different pathways. The first is the Homology Directed Repair (HDR) and the second is Non Homologous End Joining (NHEJ). 
2/ What influences how the repair is made? This come from a few factors. The first is that NHEJ is the most dominant of the 2 repair pathways. Homology Directed Repair (HDR) is only used when a sister chromatid is available.
