Discover and read the best of Twitter Threads about #crossreactivity

Most recents (2)

1/x Platelets Can Associate With SARSCoV2 RNA and Are Hyperactivated in C19 (17/9/2020)

“...HYPERCOAGULATION and THROMBOSIS contribute to lethality of [C19].
Platelets are chiefly implicated in thrombosis.
[platelets] CAN interact with viruses”…
2/x Con’t quote,

“platelets hyperactivated in C19 subjects presenting nonsevere & severe symptoms,
with AGGREGATION occurring at suboptimal #thrombin concentrations

...platelets adhered more efficiently...

Platelets may...contribute to overwhelming THROMBO-INFLAMMATION in C19”
3/ Quoting

“[platelets] are an important source of inflammatory mediators.
While a LOWER PLATELET COUNT is associated with severity/mortality, little is known about platelet function during C19.”

What causes LOWER platelet count
and platelet AGGREGATION
in some C19 patients?
Read 190 tweets
"The live SARS-like coronavirus SL-CoV-WIV1 has been isolated for the first time from bat droppings; and such virus has been confirmed to invade the host cells through the ACE2 of human beings..." ImageImageImage
Bat Severe Acute Respiratory Syndrome-Like Coronavirus WIV1
Encodes an Extra Accessory Protein, ORFX, Involved in Modulation of the Host Immune Response. (2016) #ZhengLiShi #PeterDaszak #EcoHealth
Funding: #NIAID 110964 ImageImageImageImage
In this study, we have developed a fast and cost-effective method
for reverse genetics of coronaviruses by combining two approaches developed by others..As the genomes can be divided into multiple short fragments, mutations can be introduced into individual
fragments easily. ImageImageImageImage
Read 68 tweets

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