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As this thread is gathering all kinds of perspectives, below are mine, including on a bit of history. But before that, just to say that I very much value the hard work by all the people who make #cryoEM image processing better for everyone, both in academia and in industry.
In 2012, I introduced a regularised likelihood approach for #cryoEM structure determination, which formed the basis for #RELION. This approach proved to be hugely successful and is now the basis of many software packages, including also #cryoSPARC.
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When #RELION started to replace #EMAN and #SPIDER, and before #cryoSPARC, I expressed in multiple talks that the #cryoEM field needed more diversity in software, as a monoculture is vulnerable. I used the picture below in my talk at the 2014 NRAMM course.
