Discover and read the best of Twitter Threads about #cytology

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1/2020 Massive pericardial effusion in an elderly male. Metastatic lung adenocarcinoma. #cytology #CytoPath #cellblock #lungca Pap stain, MGG, cell block and IHC.
1. Multilayered cell balls, smooth outlines, psammoma body 2. Acini in CB @kriyer68 @smlungpathguy @VijayPatho ImageImage
@kriyer68 @smlungpathguy @VijayPatho @drsys02 @Swathiprabhu5 @pathridle_susan @nandishvs * Reactive mesothelial cells can show atypia & proliferation spheres, however - knobby oultline
* Proliferation spheres (cell balls) are solid with stromal cores in mesotheioma unlike carcinoma
* Mesothelial cells: peripheral condensed cytoplasm, vacuoles (intercellular windows) Image
* PsB in pleural and pericardial effusions are usually seen in malignant effusions - thyroid, ovary, lung etc.
* In peritoneal effusion however, PsB may be associated with benign mesothelial hyperplasia, endometriosis etc
* Not all ca. show cell balls- SCC, ILC, Signet ring ca
Read 5 tweets
#Tweetorial: Diagnosis of Malignant Pleural Effusion (#MPE) to accompany publication in @AnnalsATS: bit.ly/2XM65pD

⚓️#MPE: Pl. Effusions (#pleff) w/ neoplastic cells/tissue
⚓️Paramalignant eff: related to malignancy but not due to it eg: endobronchial obstruction or PE
Answer me this dear folks!
Why is it important to diagnose #MPE?

While you ponder, LUNG and BREAST are commonest primaries metastatic to the pleural space! PMID: 24360987
#MPE = poor prognosis, change management & may help locate primary!

Ferrer (PMID: 15764788): >=4 of these strongly suggest #MPE:
a) Dyspnea, chest pain, constitutional sympt
b) Symptoms >1 mo
c) No fever
d) Blood-tinged #pleff
e) CT suggestive (mass, atelectasis, adenopathy)
Read 18 tweets

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