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#LymeDisease diagnostic tests were designed to detect cases of *late Lyme arthritis*, a condition associated with certain genetics and which usually manifests as a single arthritic knee. This is the visual CDC uses ⤵️ 
People who have the genetic makeup for susceptibility to *late #Lyme arthritis* tend to produce a strong antibody response to #LymeDisease infection, but it builds over time. That’s why CDC & IDSA say “don’t test in the first 3 weeks.”
According to CDC & IDSA, #LymeDisease is *defined* by this small subset of people who are able to test positive by serology (antibody tests).
It should be the other way around: Define the disease, then establish testing that accurately diagnoses >95% of cases meeting criteria.
It should be the other way around: Define the disease, then establish testing that accurately diagnoses >95% of cases meeting criteria.
