Discover and read the best of Twitter Threads about #dcvax

Most recents (6)

@annenbcnews
Hi Anne, my husband was dx w/ a #GBM in May 2022. I'm confused by how you did a GBM story w/o discussing the most significant development ever for brain tumors.

Please follow up with #UCLA & #NWBO #DCVAX. Completed P3 last May, approved for UK Specials already &
1/
is a personalized, nontoxic vaccine. It has given patients w/ a 10-18 month prognosis 9, 12, 16, 20+ years & counting with no addtl treatment.

My husband is a 52 yo firefighter and we are counting on #DCVAX to save his life. He doesn't have time for the treatment you covered
2/
This vaccine was created in the US and UK will have full approval before the US, forcing US patients like @Clairotonin, a 36 yo ICU nurse who desperately needs it, to try to get to the UK at a cost of $300k

We need #DCVAX approved by @US_FDA for compassionate use ASAP and
3/
Read 5 tweets
@BerkeleyJr
While I'm glad you covered #GBM tumors, you missed the headline. Instead of sharing the incredible successes of #NWBO #DCVAX and how many patients have gone 9, 12, 16, 21 years and counting w/ no addtl treatment, you focused on a Phase 2.

1/
Phase 3 was presented last May. JAMA included in their journal and 60 top docs signed on. Plus the combo trial with Keytruda and Poly-ICLC is incredible.

#DCVAX is helping people NOW. It was created at UCLA and trials were conducted in the UK, CANADA, and GERMANY too.

2/
The UK has already approved for Private Pay/ Compassionate Use and full approval should be soon.

As the wife of a #GBM patient who lost her father-in-law to this horrid disease 22 years ago, I wish you would've included the most hopeful and current option, #DCVAX.

3/
Read 5 tweets
@JasperSaberi1 @BMT094

🧵 Hi Jasper, my pleasure! Without coming off like a stock pumper, given your interest I thought I would share a little more $NWBO with you & anyone else who might be intrigued. To clarify my interest in this is indeed financial but also personal...
as I have witnessed the affects of cancer up close & personal!

$NWBO completed it's #DCVax P3 trial (Trial: NCT00045968) last year after 14yrs. The results are published in JAMA Oncology authored by a Who's Who of 70 World's top Neuro-Oncologists. The results are seminal...
jamanetwork.com/journals/jamao…

"adding DCVax-L to SOC was associated with a clinically meaningful and statistically significant improvement in median OS for patients with both nGBM & rGBM"

Most significant results in nGBM for 17 years.
Most significant results in rGBM for 27 years!
Read 28 tweets
Exploring Adjuvants with #DCVaxL: POLY ICLC TLR 3 Agonist adjuvant discussion, #DrLindaLiau, early trial P 1. Using adjuvants w/ #DCVaxL $NWBO #Murcidencel #DCVax

Survival Data w/Adjuvants, small early trial:
Fuller Discussion re early trial with #DCVaxL + adjuvants, including Poly ICLC:
Re single agent checkpoint inhibitors, without DCVaxL, in Glioblastoma:
Read 13 tweets
DCVax-L Phase 3 Trial Results

Final Top Line Results, Phase 3.

Delivered 5/10/22 to the New York Academy of Sciences by

Dr. Paul Mulholland, MBBS, MSc, PhD, FRCP, University College Hospital, UK

#DCVaxL $NWBO #TLD

via @YouTube
If you watch this by idea closely, you’ll note that the trial coins not proceed ethically UNLESS it was a crossover style. But all the patients lived longer including the recurrent ones who got access to #DCVaxL late. THAT was their placebo arm originally. There is no way in hell
, in my opinion, that a regulator is going to push a drug company into a crossover trial ethically, and then say, oh, man, your drug is so successful in making everyone live longer, but there is nothing that can be done. You fail! That’s not how regulation works.
Read 9 tweets
1/ Re $NWBO and #DCVaxL aka "ATL-DC" in brief:

#DrLindaLiau, principal investigator for a Phase 3 #DCVaxL trial recently gave a lecture covering the #DCVaxLComboTrial with #Keytruda.
2/ $NWBO and UCLA have a patent application pending approval for immunotherapy combinations with #DCVaxL.
3/ The #DCVaxLComboTrial appears to be intended to further the patent process and also to likely advance new commercial opportunities, including potential partnerships, for $NWBO. Many commentators have suggested some obvious potential partners.
Read 33 tweets

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