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We often check SPEP and/or immunofixation in patients with neuropathy. Why bother, and what should I do with the results?
Welcome to Paraproteinemic Neuropathy: A #tweetorial for neurologists who order tests they have no business interpreting.
We often check SPEP and/or immunofixation in patients with neuropathy. Why bother, and what should I do with the results?
Welcome to Paraproteinemic Neuropathy: A #tweetorial for neurologists who order tests they have no business interpreting.
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For starters, let's clear the air about terminology. These are all synonyms:
- Paraproteinemia
- Monoclonal gammopathy
- M-protein
- M component
They all mean identical plasma cells are overproducing identical copies of the same immunoglobulin or immunoglobulin fragments.
For starters, let's clear the air about terminology. These are all synonyms:
- Paraproteinemia
- Monoclonal gammopathy
- M-protein
- M component
They all mean identical plasma cells are overproducing identical copies of the same immunoglobulin or immunoglobulin fragments.
3/
Paraproteinemia is common as we age. It's usually benign (MGUS) and asymptomatic, but can be associated with almost ANY neuropathy syndrome.
(PSA: If you do a Google image search for Stocking and Glove looking for neuropathy pics, be prepared to find a bunch of S&M sites.)
Paraproteinemia is common as we age. It's usually benign (MGUS) and asymptomatic, but can be associated with almost ANY neuropathy syndrome.
(PSA: If you do a Google image search for Stocking and Glove looking for neuropathy pics, be prepared to find a bunch of S&M sites.)
