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Read our latest analysis from the #ADVOR trial @JACCJournals. Deeper dive into the relationship of #natriuresis with decongestion & clinical outcomes after diuretic therapy in acute #heartfailure! Tweetorial below...
authors.elsevier.com/a/1h4wr2d9GHwT…
@PieterMartensMD @WilfriedMullens
authors.elsevier.com/a/1h4wr2d9GHwT…
@PieterMartensMD @WilfriedMullens
First, look at detailed #ADVOR protocol below:
onlinelibrary.wiley.com/doi/full/10.10…
We did 2 consecutive urine collections:
1. Randomization => First morning (<24 h)
2. First morning => Second morning (=24 h)
If in those 2 collections, cumulative urine output <3.5 L ➡️ Failed decongestion!
onlinelibrary.wiley.com/doi/full/10.10…
We did 2 consecutive urine collections:
1. Randomization => First morning (<24 h)
2. First morning => Second morning (=24 h)
If in those 2 collections, cumulative urine output <3.5 L ➡️ Failed decongestion!
Allocation to #acetazolamide clearly increased:
✅total urine output (+12.6%)
✅total natriuresis (+26.9%)
In relative terms: effect on natriuresis > urine output, UO🚫significant after 1st diuretic dose, natriuresis remained high!
*Normalized UO to 24 h for collection 1.
✅total urine output (+12.6%)
✅total natriuresis (+26.9%)
In relative terms: effect on natriuresis > urine output, UO🚫significant after 1st diuretic dose, natriuresis remained high!
*Normalized UO to 24 h for collection 1.
Really proud moment for me today, presenting 1st time in a Featured Science session @AHAScience.
Deeper insight in #ADVOR trial with key contributions from @WilfriedMullens @PieterMartensMD @JeroenDauw @petra_nijst @EvelyneMeekers among many others. Proudly 🇧🇪!
Tweetorial below!
Deeper insight in #ADVOR trial with key contributions from @WilfriedMullens @PieterMartensMD @JeroenDauw @petra_nijst @EvelyneMeekers among many others. Proudly 🇧🇪!
Tweetorial below!
From #ADVOR population, we included 462 or 89% of patients with 2 correctly performed consecutive urine collections and urine sodium concentration (UNa) available.
Natriuresis:
- UNa [mmol/L] ~ diuretic efficiency
- Total natriuresis [mmol] ~ ECV & interstitial Na buffer removed
Natriuresis:
- UNa [mmol/L] ~ diuretic efficiency
- Total natriuresis [mmol] ~ ECV & interstitial Na buffer removed
#Acetazolamide, after multivariate adjustment, was strongest predictor of #natriuresis in #ADVOR:
UNa + 16 mmol/L
Total natriuresis +115 mmol
👊 within 2 days !!!
👍 much stronger than effect on urine output itself
"#acetazolamide keeps the urine salted"
UNa + 16 mmol/L
Total natriuresis +115 mmol
👊 within 2 days !!!
👍 much stronger than effect on urine output itself
"#acetazolamide keeps the urine salted"
