Discover and read the best of Twitter Threads about #diagnostics

Most recents (22)

Linux Diagnostics and Troubleshooting Series -

Thread 4 👇

IDENTIFYING HARDWARE ISSUES!

#Linux #diagnostics #troubleshooting #security PC: https://content.nexus.support.com/5b557b9559124044bb566b
Identifying hardware -
An important step in troubleshooting potential hw issues is knowing exactly which hw is present in a system. For virtual systems, this might seem less useful than for a physical system, but it can tell an admin if the correct virtual devices have been added
Identifying CPUs -

The CPU(s) in a running system can be identified with the lscpu command from the util-linux package.

# lscpu
Read 32 tweets
Linux Diagnostics and Troubleshooting Series -

Thread 1 👇

Understanding what Troubleshooting is!

#Linux #diagnostics #troubleshooting #security
What is troubleshooting?

Troubleshooting is the art of taking a problem, gathering information about it, analyzing it, and finally solving it.

While some problems are inherently “harder” than others, the same basic approach can be taken for every problem. PC: https://knowmax.ai/wp-content/uploads/2020/09/Troublesho
Not just fixing!

While fixing a problem is one of the major parts of troubleshooting, there are other parts that cannot be neglected: documenting the problem (and fix), and performing a root cause analysis (RCA). PC: https://knowmax.ai/wp-content/uploads/2020/09/Troublesho
Read 16 tweets
1/ Happy Friday!
Today I am celebrating #scicomm! As of this week, I have contributed 21 articles to the @ASMicrobiology Bugs & Drugs blog! Here's a recap of some of these articles for those who love clinical #microbiology
#IDTwitter @ASCLS @CUAnschutz #MedEd @JClinMicro
2/ First, just a quick note on writing for @ASMicrobiology. Volunteering my time to write has been one of the highlights of the last 2 yrs for me! So grateful for the amazing Bugs & Drugs team, especially @JulieMarieWolf @JClinMicro @ScienceInTheDMV who took a chance on me.
3/
YELLOW FEVER AND FRACTIONAL DOSES
#Publichealth piece discussing the yellow fever outbreak of 2015/16 in Africa & highlighting the amazing work of researchers working on fractional #vaccine dosing. It's an amazing story, full of impressive characters.
asm.org/Articles/2021/…
Read 19 tweets
1/ I loved writing this new @ASMicrobiology article. I talked to Dr. Derick Kimathi (@Toinoti, medical researcher in Kenya), about using fractional doses of yellow fever #vaccine. I hope you find this as interesting as I did #IDtwitter #epitwitter
asm.org/Articles/2021/…
2 / This is a follow up article to the one I wrote back in May that briefly detailed the history of #YellowFever in the United States, and how the development of #diagnostics for the disease as well as modern research stemmed from that #history.
asm.org/Articles/2021/…
3/ The #YellowFever #outbreak that started in Angola in 2015 ravaged major cities like Luanda & Kinshasa, and resulted in 11 imported cases in China - a country that harbors the mosquito that spreads the yellow fever virus and has a population immunologically naïve to YF.
Read 8 tweets
The recent outbreaks of #Zika Virus in #Kerala has renewed interest in this virus. This tweetorial explains some key aspects about the virus and why we should be actively using #genomics for #GeneticEpidemiology Image
The disease in most people is mild. Majority of people infected with Zika virus DO NOT develop symptoms. Symptoms are generally mild including fever, rash, conjunctivitis, muscle and joint pain, malaise, and headache, and usually last for 2–7 days.
Source: @CDCgov Image
Death is RARE
Infection during pregnancy can cause microcephaly & congential malformations.
Neurological complications like Guillain-Barré syndrome, neuropathy and myelitis are seen in some.
Read 13 tweets
1/16 THREAD🧵3 years ago I proposed that #Psychedelic-Assisted Psychotherapy (PAP) is a #ParadigmShift in psychiatry. The paper has been viewed almost 80k times around the globe and sits at the top 1% views/downloads and top 8% citations of the whole @FrontiersIn journal series.
2/16 Published in the special issue “Psychedelic Drug Research in the 21st Century” it has 82 citations at Google Scholar and was included in one slide by Javier Muñiz, from the FDA’s division of psychiatry, at his ISRP lecture in Oct/2019 frontiersin.org/articles/10.33…
3/16 My perspective on the psychedelic impact on psychiatric research and development was based on Prof. @rose_nikolas useful critique of the current situation in psychiatry as a triple crisis
cambridge.org/core/journals/…
Read 16 tweets
(Thread 1/n) The Future of Health & #Medicine: Where Can Technology Take Us?

@daniel_kraft eloquently summarizes the early innings of #healthcare #technology, and its #future. #mustwatch
$XBI $IBB

My favorite takeaways below:

(Thread 2/n) The Future of Health & Medicine:
Where Can Technology Take Us?

Some companies discussed: $TDOC $DRIO $GDRX $AMZN $UBER $AAPL $FIT $AMWL $GOOGL
$GRMN $DXCM $TNDM

@TeladocHealth (I think) would be wise to purchase
@DetectTest @VitalConnectInc @TytoCare @HeartFlow ImageImageImageImage
(Thread 3/n) The Future of Health & Medicine
Glucose Monitoring paving the path forward.

Diabetes care started the path forward. Wearable monitoring, is still in it's infancy. What other applications will come?

@dexcom
@TandemDiabetes
@DarioHealth
@TeladocHealth @Livongo ImageImageImageImage
Read 22 tweets
@ThinkingAboutV @nanopore The applied omics market based on #NGS technology is still an incipient market if we compare it to more established #diagnostics markets. But we are not far away from a point in time where every newborn's genome is ...
@ThinkingAboutV @nanopore ... sequenced at high quality (long reads, maybe with PCR-free including epigenome marks), and kept as an #EHR in the health system for future use. From then onwards, there will be recurrent #LiquidBiopsy assays, maybe once a year, to screen for a multitude of conditions.
@ThinkingAboutV @nanopore From 40-45 yo onwards, mainly cancer screening of healthy individuals, based on a #MachineLearning cancer classifier such as shown already by @GrailBio / $GH and others, but also other classifiers will come soon, such as #epigenomic profiling of #Neurodegenerative conditions, ...
Read 7 tweets
While COVID19 is grabbing world attention, another global public health threat is still rising in the wings - #AMR. By 2050 AMR could cause 10 million deaths if left unchecked. AMR is not new and its history stretches back long before penicillin. whatisbiotechnology.org/index.php/exhi… /1 Image
The first case of drug resistance was noted in 1907 by #PaulEhrlich, when he observed mice infected with Trypanosoma brucei developed resistance with repeated doses of #Salvarsan, the first compound found to have antimicrobial activity. whatisbiotechnology.org/index.php/exhi… /2 Image
Another drug spotted to cause resistance was Optochin, an antimicrobial agent used to treat pneumonia. The first instance of resistance was noted in mice, infected with pneumococcal bacteria, in 1910, and then in humans in 1913. /3 Image
Read 27 tweets
#JPM2021 #LiquidBiopsy notable by their absence, which is more than excusable in these pandemic times: @freenome, Biocartis, Biodesix, Epic Sciences, ArcherDx (not by this name anyway). Worth following developments for them. In my book, worth following #Freenome of the ones here.
Smaller #LiquidBiopsy #Oncology #Diagnostics players also not at #JPM2021 but important in the field: Personalis, Inivata, Exosome Diagnostics, Epigenomics Ag, Personal Genome Diagnostics, Foundation Medicine, Singlera, Cambridge Epigenetix, and Bluestar Genomics.
Now added #BiologicalDynamics to my #LiquidBiopsy list crunchbase.com/organization/b… which displace #Biocept in the #Top30 bit.ly/liqbiop (thanks Kevin Han for the follow).
Read 5 tweets
Surprised to see how little interest scientific journals have in #SARSCoV2 #COVID19 antigen #rapidtest test validations at the point of care, although guidance from such studies could have a huge public health impact for their implementation #diagnosticsmatter @FINDdx 1/n
We have recently performed this study medrxiv.org/content/10.110… for 2 commercial Ag-RDTs in a high prevalence setting (PCR positivity rate >20%), showing: high sensitivity of 87.6% and excellent specificity of 99.9% in symptomatic individuals compared to RT-PCR 2/n
These findings could contribute a lot to optimized selection criteria for Ag-RDT testing: In patients presenting with fever/chills and 1-5 days post symptom onset, sensitivity was above 95%. Sensitivity was less on the same day of symptom onset (still increasing viral load?) 3/n
Read 6 tweets
Happy 2021! @MBVanElzakker and I are excited to share our new article published in #Immunometabolism: “Pathogens Hijack Host Cell Metabolism: Intracellular Infection as a Driver of the Warburg Effect in Cancer and Other Chronic Inflammatory Conditions”: ij.hapres.com/htmls/IJ_1341_…
2/ In the paper, we detail molecular mechanisms by which #viral, #bacterial, and #parasite intracellular pathogens can induce, or contribute to, a Warburg-like #metabolism in infected host cells in order to meet their own replication and nutritional needs.
3/ We also discuss how host defense towards #infection may impact cellular metabolic changes (including how #mitochondria can participate in the innate immune response towards infection)
Read 9 tweets
Dr @HouptEric started the session on Hot Topics in #TB with an overview of #diagnostics and where we are headed #IDWeek2020 @UVA_ID @Tacats99
Our second speaker is DrCaitlin Reed starts us with a case of MDR TB with definitions and how to build a regimen #IDWeek2020
Discussing the recommendations from current @IDSAInfo guidelines idsociety.org/practice-guide… #IDWeek2020 and more clinical trials to shorten the duration 😱😱#TB
Read 5 tweets
Indian Diagnostic industry is ~USD 9bn; expected to grow at 10% CAGR over next 5years
edelweiss.in/research/secto…
@EdelweissWM @MetroHealthLab @drlalpathlabs #indiandiagnostic #Indianhealthcare #diagnostics #healthcare
Refferrals still constitute major part in diagnostic sector
National Diagnostics chains outperform the sector: 21% sales CAGR over last ten years #diagnostics #metropolishealthcare #drlalpathlabs
Read 14 tweets
Starting in a couple of minutes:
#COVID19: Updates from #Singapore, a weekly seminar on the #coronavirus situation in Singapore

This week's guest is @mpkieny.

Hosted by: @profdalefisher, Dr. David Allen

@WHOGOARN
Registration webpage:
medicine.nus.edu.sg/cet/webinar/
Fall in #COVID19 death rate in past few months, situations in most regions appear to be stabilising

@profdalefisher
Read 25 tweets
Daily Bookmarks to GAVNet 5/18/2020-2

Interpreting Diagnostic Tests for SARS-CoV-2 | JAMA | JAMA Network

jamanetwork.com/journals/jama/…
#testing #coronavirus #diagnostics
Tools for Culture Design: Toward a Science of Social Change?

slideshare.net/joebrewer31/to…
#tools #culture #design
Why this crisis is a turning point in history

newstatesman.com/international/…
#TurningPoint #History #crisis
Read 8 tweets
21 WAYS TO SPIN RESULTS FROM A COVID DIAGNOSTIC TEST ACCURACY (morning thoughts whilst walking the dog - please add others I've missed). I'm putting this out to help us critique the "number theatre" being thrown at us.
#diagnostics #COVID19 @deb_cohen @MHRAgovuk @drhelmac
1/22
#1 Use a small sample size (and never report how big it isn’t). Use phrases like"we detected all cases" the test is "100% accurate" without mentioning it is only from 29 samples.
2/22
#2 Talk about the total sample size when interpreting results about sensitivity (especially if you have tested 5000 blood donors to estimate specificity and only 29 to estimate sensitivity)
3/22
Read 23 tweets
Thoughts on upcoming #COVID19 #serology tests:
This is actually quite a challenge! (#Diagnostics often involve a lot of complexities). There is a lot of pressure to roll these tests out, but they need to perform well, or we do more harm than good. #MicroRounds (A thread)
WHY we need these soon:
1. Contact tracing.
2. Can be used to test if a vaccine is working during a clinical trial (70 of them ongoing right now, I believe)
3. Inform public policy makers about rate of asymptomatic cases + previous infections/exposures =informed decision making
How is developing a #PCR different than developing a #serology test?
1. #PCR tests detect viral RNA/DNA (in this case RNA) and can be pretty straight-forward in terms of development
2. #Serology relies on knowing about the #SARSCoV2 structure and how the human body responds.
Read 13 tweets
On this week's @ARKInvest newsletter, I'm going to talk about how #synthetic #biology (not reading, but writing DNA) is a crucial (but not widely talked about) part of our ability to rapidly develop tests and treatments for #COVID19. Until then, ask questions and I'll post links.
Synthetic biology (#SynBio) = creating DNA molecules artificially

In this case, it means synthesizing #COVID19 fragments to aid in the design, validation, and quality control of diagnostic tests. It also helps us research different viral strains and potential therapeutics.
First, I want to tackle 'spike-in' controls for validating RT-PCR assays for #COVID19 detection. Detailed write-ups below and then I'll post a summary (or TL;DR)...

mcb.asm.org/content/mcb/36…
cofactorgenomics.com/6-changes-that…

synbiobeta.com/twist-bioscien…
Read 7 tweets
1/ Reducing technical bias during genetic analysis is a major challenge for molecular #diagnostics. By involving #DNA reference sequences, researchers can compare theoretical and actual test results in hopes of improving test sensitivity.
2/ However, contemporary references have the capacity to contaminate and confound analysis, making it challenging to continue optimizing test accuracy beyond a certain limit. A recent study exploited a common chemical characteristic called ‘chirality’ to build a new class of...
3/ ...synthetic, internal references for sequencing assays. #Chiral molecular are distinct from their mirror image—similar to how one’s hands, though perfect reflections, cannot be superimposed. Implementing these chiral sequences (sequins), the researchers were able to...
Read 5 tweets
Closing the loop on #Diagnostics #Tweetorial with example #AppleWatch #AFib #Screening. From a company website: "Atrial fibrillation is a silent killer. The heart arrhythmia causes more life-threatening strokes than any other chronic condition, and will affect 1 in 4 of us."
"But the sad fact is that atrial fibrillation often goes unnoticed: It is estimated that 40% of those who experience the heart condition are completely unaware of it."
Using #AppleWatch technology and #DeepLearning #AI #ML, a device algorithm can reportedly detect atrial fibrillation with high accuracy (c-statistic 93%).
Read 44 tweets
#Tweetorial on #Diagnostics and #Screening interpretation.
An otherwise healthy 40 year old woman comes to you after reading on the internet about a terrible disease that one in a thousand women get, and a highly accurate test that can save her life.
The test is over 99% accurate in people with the disease. For those without disease, the test is only wrong 5% of the time.

You order this test and it comes back positive. The woman anxiously asks you, do I have the disease? What is the chance this woman has the disease?
Assuming they weren't immediately fooled by the "test is only wrong 5 % of the time," most I've asked correctly recognize the stats provided are Sensitivity = 99% and Specificity = 95%, and that the objective is to determine the Positive Predictive Value.
Read 21 tweets

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