Discover and read the best of Twitter Threads about #dnamethylation
Most recents (2)
New preprint! 🥳
biorxiv.org/content/10.110…
Led by @aledjohnparry & @ChristelKrueger we asked why #DNAmethylation and oxidation often target overlapping genomic regions at the exit of #pluripotency.
Great collaboration with @Tim_Lohoff, @StevenWingett & @stefanschoenfe1.
🧵👇
biorxiv.org/content/10.110…
Led by @aledjohnparry & @ChristelKrueger we asked why #DNAmethylation and oxidation often target overlapping genomic regions at the exit of #pluripotency.
Great collaboration with @Tim_Lohoff, @StevenWingett & @stefanschoenfe1.
🧵👇
Excellent work by @SchubelerLab, @rulandsgroup, Jaenisch lab, Meissner lab, @CarellThomas and others has shown that DNA methylation turns over genome wide as cells exit naïve pluripotency, especially at enhancer elements.
We discussed this here: rdcu.be/b8bfM
We discussed this here: rdcu.be/b8bfM
But what is the function of methylation turnover?
To find out, we modelled pluripotency exit in vitro (transitioning ESCs to EpiLCs) and performed a thorough molecular characterisation in wild type cells and in cells lacking DNA methylation (Dnmt TKOs) or oxidation (Tet TKOs).
To find out, we modelled pluripotency exit in vitro (transitioning ESCs to EpiLCs) and performed a thorough molecular characterisation in wild type cells and in cells lacking DNA methylation (Dnmt TKOs) or oxidation (Tet TKOs).
1/ New insights into control of #tregs by #DNAmethylation from #SingerLab. #epigenetics @luisamnMD @NMPulmCritCare
Check out our new preprint on @biorxivpreprint: biorxiv.org/cgi/content/sh…
Check out our new preprint on @biorxivpreprint: biorxiv.org/cgi/content/sh…
2/ Treg cells are known to require a lineage-specific DNA hypomethylation pattern during development that stabilizes their lineage. We wanted to determine whether maintenance DNA methylation is required for Treg cell lineage development and stability.
3/ Accordingly, we bred mice with Treg cell-specific deficiency in the epigenetic regulator Uhrf1, which maintains methyl-DNA marks. These mice displayed a profound inflammatory phenotype.
