Discover and read the best of Twitter Threads about #dnamethylation

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New preprint! 🥳

biorxiv.org/content/10.110…

Led by @aledjohnparry & @ChristelKrueger we asked why #DNAmethylation and oxidation often target overlapping genomic regions at the exit of #pluripotency.

Great collaboration with @Tim_Lohoff, @StevenWingett & @stefanschoenfe1.

🧵👇
Excellent work by @SchubelerLab, @rulandsgroup, Jaenisch lab, Meissner lab, @CarellThomas and others has shown that DNA methylation turns over genome wide as cells exit naïve pluripotency, especially at enhancer elements.

We discussed this here: rdcu.be/b8bfM Image
But what is the function of methylation turnover?

To find out, we modelled pluripotency exit in vitro (transitioning ESCs to EpiLCs) and performed a thorough molecular characterisation in wild type cells and in cells lacking DNA methylation (Dnmt TKOs) or oxidation (Tet TKOs).
Read 12 tweets
1/ New insights into control of #tregs by #DNAmethylation from #SingerLab. #epigenetics @luisamnMD @NMPulmCritCare

Check out our new preprint on @biorxivpreprint: biorxiv.org/cgi/content/sh…
2/ Treg cells are known to require a lineage-specific DNA hypomethylation pattern during development that stabilizes their lineage. We wanted to determine whether maintenance DNA methylation is required for Treg cell lineage development and stability.
3/ Accordingly, we bred mice with Treg cell-specific deficiency in the epigenetic regulator Uhrf1, which maintains methyl-DNA marks. These mice displayed a profound inflammatory phenotype.
Read 13 tweets

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