Discover and read the best of Twitter Threads about #dnarepair

Most recents (4)

Excited to share our latest preprint titled "Deficiency in DNA mismatch repair of methylation damage is a major mutational process in cancer"… #Cancer #DNARepair
MMR is well known for its role in the repair of mismatched base pairs that escape proof-reading by replicative DNA polymerases. However, more than 4 mutational signatures have been associated with MMR deficient cancers. What are their underlying processes?
To find out what these processes might be, we carefully classified MMR deficient cancers (aka MSI cancers) from TCGA based on whether they are MutSα (mismatch recognition) or MutLα (nuclease) deficient. Image
Read 9 tweets
Livetweets from the 7th Annual Aging Research and Drug Discovery conference #ARDD2020. I can't attend every talk to coverage will be intermittent. Apologies to any speakers left out!
Christian Riedel from @karolinskainst presenting aging clocks. There are a lot of these, but excited to see him (A) making a human clock predicting time to death, not just age, and (B) deconvoluting both their human and model org clocks into FUNCTIONAL parameters. Sorely needed.
Now from Estonia arguing that hand photos are more robust than faces for AI-based aging biomarkers, and that we need more explicit skin tone features for broadly applicable tools.
PS, Estonia is probably the world leader in digital health/EHRs.
Read 24 tweets
Bird’s-eye view 👁 on what to look out for @WCGIC #WorldGI2020.
Opening remarks on important data 📺 @myESMO - by Dr. Eric Van Cutsem @UZLeuven.
🟩Good to see more #PrecisionMedicine🧬
🟥#Immunotherapy #Immuno-#oncology
🟦TNT & other chemo strategies
@Annals_Oncology #OncoAlert
🆕#ctDNA #liquidbiopsies 🩸🧬
👀 👇🏾at the number of #clinicaltrials cropping up in this space‼️
We have 2🇺🇸studies open. #CRCSM #WorldGI2020
#WORLDGI2020 This is 🆒 ☢️ 32-P EUS-guided implantation in #pancreascancer #PANCSM @myESMO @WCGIC @Annals_Oncology.

Still miles to go. OS median of 16 months pointing again to the systemic nature of disease. Need to piggyback these local approaches to better systemic. #OncoAlert
Read 55 tweets

تحت هالتغريدة حتكلم في سلسلة تغريدات عن السرطان، إيش هو؟ وكيف يتكون؟ إيش هي صفاتة الجزيئية؟ ووين وصلنا في حربنا معه؟ أطلق على هالسلسلة عنوان: #الخلية_المجنونة
بدأت أبحاث السرطان بالإنطلاق الفعلي في بداية السبعينات، بعد أن أعلن الرئيس الأمريكي الراحل نيكسن حربه على السرطان في خطابه المشهور عام 71. تأثرت أبحاث السرطان في تلك الفترة بثورة البيولوجيا الجزيئية في ذاك الوقت الي تفجرت بعد الإكتشاف العظيم للحمض النووي #DNA في الخمسينات.
الخلايا الطبيعية في الجسم تعيش وفق نظام محكم، ماتنقسم إلا عند الضرورة وبعد ما تتأكد إن الجينات الي داخلها مافيها أي خلل. إذا كان في خلل تصلحه قبل ماتنقسم #DNArepair، وإذا ماقدرت تصلحه تنتحر عبر عملية الموت المبرمج #Apoptosis. هذي الخواص مهمة للحفاظ على أنسجة الجسم من تكون الأورام
Read 16 tweets

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