Discover and read the best of Twitter Threads about #dose

Most recents (3)

Conversations between #Turtle & #MP
Few days before heading to Ireland, MP is coming home late after working all day on presentations he is invited to give @ECMP2022 in #Dublin, surprised to see his buddy slowing coming up his driveway.

MP: Hey buddy, what are you doing?

MP: It might have taken U some time to come all the way from park

Turtle: Yes doc, I heard U were heading to @TourismIreland island & wanted to join U. Since it would take me more time & I didn’t want to rush, I thought I will come over & rest behind your house till we leave
MP: What do U mean & how did U know?

TL: Well, my 3rd cousin from my mom side who lives in #WicklowMountains close to Dublin told me that you were coming there soon

MP: What, how did she know?

Read 13 tweets
1. Relating to the approval/start of emergency #COVID19 vaccine dose - 4th #dose and vaccinating lower age groups of children:

Is there any #emergency now?

Global #Deaths are now all-time low since the start of mass #vaccination. #Cases are also not rising. (plots attached) ImageImage
2. For #India #COVID19 Deaths and Cases are now all-time low since beginning of #pandemic (plot)! Hence not at all an #emergency; instead, heading towards normalcy after two years.

There is indeed not an emergency for US too (plot).

Then why any emergency approval/#rollout? ImageImageImage
3. Israel began vaccinating 5–11 years old in Nov, 2021 and initiated the fourth #dose during Jan, 2022. Israel in fact is leading/ guiding the vaccine rollout strategy.

For #Israel, the recent peak not only in Cases but also for Deaths reached an all-time high (plot). Image
Read 13 tweets
#Tenecteplase #TNK
Part 1
✅3rd generation rtPA
🧬Targeted genetic upgrade
3 specific alterations to #alteplase molecule:
👉⬆️Half life
👉⬆️Binding affinity for #fibrin
👉⬆️Resistance to inactivation by #PAI-1 Image

👉⬆️T1/2 allows single bolus dosing and⬆️clot exposure to TNK
👉Higher affinity to fibrin-rich clots & + potent/faster clot #lysis vs alteplase
👉 < consumption of fibrinogen/plasminogen/ a2- antiplasmin👉⬇️systemic fibrinolytic effect👉⏬risk for bleeding Image
First analysis in stroke patients was a #dose-scalation safety study
There was no #symptomatic ICHs in dosis of 0.1-0.2-0.4mg/kg, and 15% (2 of 13) in 0.5mg/kg
No differences in clinical outcomes ImageImage
Read 11 tweets

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