Discover and read the best of Twitter Threads about #drugcosts

Most recents (4)

THREAD: Trama-DO or Trama-DON'T?
What to know about #tramadol

1/7 Tramadol has multiple mechanisms of action:
- via serotonin & norepinephrine reuptake inhibition
- after metabolism to M1 metabolite, via opioid agonism

bit.ly/3t5o7jC #chronicpain #arthritis #MedEd
2/7 People metabolize #tramadol variably šŸ¤”šŸ’Š

- Some who are ā€˜ultra rapidā€™ produce more M1 (opioid);
- Some ā€˜poorā€™ metabolizers (~20% with inactive CYP2D6) may have more SSRI/SNRI-like effect

Thus, analgesic & adverse effects are unpredictable
ncbi.nlm.nih.gov/books/NBK315950 #MedEd
3/7 Tramadol, once called a ā€˜saferā€™ opioid, causes tolerance and withdrawal, and is associated with addiction, overdose, and death

Observational studies show people treated with #tramadol, vs other opioids, are ā†—ļø likely to engage in prolonged opiate use #chronicpain #arthritis
Read 8 tweets
Daily Bookmarks to GAVNetĀ 11/20/2020 greeneracresvaluenetwork.wordpress.com/2020/11/20/daiā€¦
Universal basic income helped Kenyans weather COVID-19 - but itā€™s not a silver bullet

theconversation.com/universal-basiā€¦

#UniversalBasicIncome #kenya #PandemicResponse #COVID19
Amazon Pharmacy is a thing because we live in hell

mic.com/p/amazon-pharmā€¦

#amazon #DrugCosts #MedicalCosts #healthcare #capitalism
Read 8 tweets
Daily Bookmarks to GAVNetĀ 10/11/2020 greeneracresvaluenetwork.wordpress.com/2020/10/11/daiā€¦
The Cure for Aging Might be the Cure for Alzheimerā€™s - Andreessen Horowitz

a16z.com/2020/10/07/agiā€¦

#alzheimer #cure #aging
Did indigenous Americans and Vikings trade in the year 1000? | Aeon Essays

aeon.co/essays/did-indā€¦

#americans #vikings #trade
Read 6 tweets
THREAD: 5 Things You Need to Know About PPIs

For many years, we've dissected the research on Proton Pump Inhibitors (PPIs) šŸ¤”

This thread captures our publications on PPIs that can help you in clinical practice: ti.ubc.ca/?s=ppis

#MedEd #medsafety #DrugEvidence #GERD
2/6 PPI COSTS VARY CONSIDERABLY šŸ’°

Even without differences in efficacy or safety between PPIs, costs can vary x 10. The cheapest in BC? Pantoprazole Mg 40mg or Rabeprazole 10mg. Most expensive: Dexlanzoprazole

More here: ti.ubc.ca/letter99

#MedEd #DrugCosts #GERD
3/6 RESPONSE IS VARIABLE

1 in 2 pts w/ acid reflux get symptom relief with a PPI (NNT~2) w/in 4-8 wks

Responders notice symptom relief w/in 1-9 days. If no relief in ~2 wks consider šŸ›‘ PPI. Non-acid reflux doesnā€™t benefit from PPI

More here: ti.ubc.ca/letter99

#MedEd
Read 7 tweets

Related hashtags

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!