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In our @LancetMicrobe paper we report 671 Mtb genomes 🧬from 391 patients with drug #resistant #tuberculosis in KwaZulu-Natal South Africa sampled over 6 years.
We screened for resistance to #bedaquiline, a drug now central to effective #TB treatment.
➡️tinyurl.com/y5zapnbk
We screened for resistance to #bedaquiline, a drug now central to effective #TB treatment.
➡️tinyurl.com/y5zapnbk
We found ~4% of patients harboured #Mtb with variants in genes known to mediate #resistance to bedaquiline/clofazimine.
Phylogenetic analyses show repeated & independent acquisitions of resistance variants, including onward transmission of resistant strains across South Africa.
Phylogenetic analyses show repeated & independent acquisitions of resistance variants, including onward transmission of resistant strains across South Africa.
Bedaquiline is a reasonably new, but now cornerstone, drug in the fight against #DRTB.
The lack of routine #bedaquiline susceptibility testing may allow these #resistant strains to continue to spread, unwatched, posing further significant challenges to #TB treatment & control.
The lack of routine #bedaquiline susceptibility testing may allow these #resistant strains to continue to spread, unwatched, posing further significant challenges to #TB treatment & control.
