Discover and read the best of Twitter Threads about #drugtargets
Most recents (1)
885 of all small molecule drugs pass the rule-of-five test; of these, 619 (70%) are actually dosed orally, whereas 159 (20%) of orally dosed drugs fail at least one of the rule-of-five parameters
-John P Overington, Bissan Al-Lazikani and Andrew L Hopkins
nature.com/articles/nrd21…
-John P Overington, Bissan Al-Lazikani and Andrew L Hopkins
nature.com/articles/nrd21…
@johnpoverington et al determine that all current drugs with a known mode-of-action act through 324 distinct molecular drug targets. 266 are human-genome-derived proteins, and the remainder are bacterial, viral, fungal or other pathogenic organism targets
readcube.com/articles/10.10…
readcube.com/articles/10.10…
Small molecule drugs modulate 248 proteins, of which 207 are targets encoded by the human genome. Oral #smallmolecule drugs target 227 molecular targets, of which 186 are human
-@johnpoverington, Bissan Al-Lazikani, Andrew Hopkins
nature.com/articles/nrd21…
-@johnpoverington, Bissan Al-Lazikani, Andrew Hopkins
nature.com/articles/nrd21…
