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Excited to announce our new method #CytoSPACE for mapping single cells from a reference atlas to #SpatialTranscriptomics (ST) data at high resolution, out now in @NatureBiotech! 1/10
nature.com/articles/s4158…
nature.com/articles/s4158…
Available assays for ST lack single-cell resolution (e.g. #Visium) or have limited gene recovery (e.g. #MERSCOPE).
CytoSPACE computationally reconstructs tissue specimens to obtain high gene coverage and spatially-resolved scRNA-seq data suitable for downstream analysis. 2/10
CytoSPACE computationally reconstructs tissue specimens to obtain high gene coverage and spatially-resolved scRNA-seq data suitable for downstream analysis. 2/10
CytoSPACE works by constrained global optimization to yield robust mappings, outperforming existing methods across benchmarks. 3/10 
