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7 quick thoughts about this important aza-ven #AML trial from #EHA25:
1) Study had specific "ineligible for intensive therapy" criteria, akin to Ferrara et al SIS/GITMO @LeukemiaJnl 2013 & ELN 2017 criteria, which we're seeing more of - positive development given past problems./1
1) Study had specific "ineligible for intensive therapy" criteria, akin to Ferrara et al SIS/GITMO @LeukemiaJnl 2013 & ELN 2017 criteria, which we're seeing more of - positive development given past problems./1
2) HMA/venetoclax turned out to be an appropriate use of the @FDAOncology accelerated approval pathway (November 2018) - but we can only know that in retrospect!
3) Median OS of 14.7 months in combination therapy arm is still pretty crummy, and shows we have more work to do./2
3) Median OS of 14.7 months in combination therapy arm is still pretty crummy, and shows we have more work to do./2
4) OS in azacitidine monotherapy control group of 9.6 months (95% CI 7.4-12.7) benchmarks with AZA-AML-001 trial result (10.4 mos) & with Austrian AGMT study group azacitidine #AML registry data (10.3 mos, 10.8 months for "AZA-AML-001 like" patients)./4
ncbi.nlm.nih.gov/pmc/articles/P…
ncbi.nlm.nih.gov/pmc/articles/P…
