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#TBTWebinar is back ‼️
🥼 @MPishvaian @BreastCancerMD1 @Latinamd @BenWestphalen
#CME🔗 bit.ly/3vdXBb4
Pretest 👉 bit.ly/3rYNZir
Claim credit 👉 bit.ly/3ljVVXM
Supported by AstraZeneca Pharmaceuticals & Daiichi Sankyo, Inc
twitter.com/i/broadcasts/1…
🥼 @MPishvaian @BreastCancerMD1 @Latinamd @BenWestphalen
#CME🔗 bit.ly/3vdXBb4
Pretest 👉 bit.ly/3rYNZir
Claim credit 👉 bit.ly/3ljVVXM
Supported by AstraZeneca Pharmaceuticals & Daiichi Sankyo, Inc
twitter.com/i/broadcasts/1…
#TumorBoardTuesday HER2 #TBTWebinar 🔑
➡️HER2 activity requires receptor dimerization
✅HER1 = EGFR
✅HER3, HER4
➡️HER2 is frequently overexpressed in multiple cancers
✅Protein⬆️due to gene🧬 amplification
✅Constitutive activation due to activating🧬mutation
➡️HER2 activity requires receptor dimerization
✅HER1 = EGFR
✅HER3, HER4
➡️HER2 is frequently overexpressed in multiple cancers
✅Protein⬆️due to gene🧬 amplification
✅Constitutive activation due to activating🧬mutation
#TumorBoardTuesday HER2 #TBTWebinar 🔑
➡️HER2 (ERBB2) alterations occur in multiple cancer types
✅Breast Ca 25%
✅Gastric Ca 22%
✅GE jxn Ca 32%
✅CRC 5%
✅Lung Ca 6 to 30%
✅Biliary Ca 5 to 20%
🤔There is some disease specificity re: overexpression vs activating🧬mutation
➡️HER2 (ERBB2) alterations occur in multiple cancer types
✅Breast Ca 25%
✅Gastric Ca 22%
✅GE jxn Ca 32%
✅CRC 5%
✅Lung Ca 6 to 30%
✅Biliary Ca 5 to 20%
🤔There is some disease specificity re: overexpression vs activating🧬mutation
