Discover and read the best of Twitter Threads about #endpoints
Most recents (3)
How well are the current #Covid vaccines performing?
In all fairness, we can say they are offering high protection against severe disease & deaths; considerable protection against the symptomatic disease; but only modest protection ag. infections/transmission of the disease 1/
In all fairness, we can say they are offering high protection against severe disease & deaths; considerable protection against the symptomatic disease; but only modest protection ag. infections/transmission of the disease 1/
To put it another way, the vaccines are contributing little to our fight against the frequent surges of the #SARSCoV2 virus.
This leads to one pertinent question:
What ought to be the prime objective of the vaccination particularly amid an intense pandemic? 2/
This leads to one pertinent question:
What ought to be the prime objective of the vaccination particularly amid an intense pandemic? 2/
To resist the ongoing outbreak or avoid hospitalizations and deaths?
A four-fold reduction in the hospitalisation & death rates is not much use if we just allow infections to reach four-fold the previous peak. 3/
A four-fold reduction in the hospitalisation & death rates is not much use if we just allow infections to reach four-fold the previous peak. 3/
Folks! We return for #HOTrainees with the exciting #Day2 @myESMO #ESMO20 and some more #practice relevant studies in #breastcancer #ProstateCancer #lungcancer #GI, so sit back, relax and lets go through some data (#HO #trainee-style!) Shout out to @peters_solange @OncoAlert
1. #BreastCancer: We have #monarchE and #IMPassion031 hoping to hear from experts @ErikaHamilton9 @NicoleKuderer @DrSGraff @matteolambe @tmprowell @GeorgeSledge51 @VukovicPetra for more insights- please link to your discussions here for #trainees:
1. A) #monarchE: use of #abemiciclib in HR+, HER2-,high risk #EBC in addition to endocrine therapy.
Current #SOC: adjuvant ET (5-10 years)
#monarchE: #Abemaciclib + ET iDFS HR 0.747, here's a great summary by @ErikaHamilton9 for @OncoAlert :
Current #SOC: adjuvant ET (5-10 years)
#monarchE: #Abemaciclib + ET iDFS HR 0.747, here's a great summary by @ErikaHamilton9 for @OncoAlert :
1/ Quelques réflexions @RecheckHealth sur la critique de l’#EBM que j’avais présentées à @MartinFierro769 @BoussageonR @cucherat @FranoisGueyffi2 @boylandry et qui montrent que si ses ennemis font ce genre de propositions #BigPharma n’aura bientôt plus besoin d’amis
2/ Le constat de récupération des instruments #EBM par #BigPharma et de leur détournement à des fins commerciales est partagé par de nombreux observateurs p.ex. Jack E James en 2017 tinyurl.com/yygrvgwa
3/ Les critiques portent notamment sur les #RCT
#BigPharma ayant (encore) besoin de #RCT avec des résultats favorables pour obtenir l'#AMM de nouveaux produits ou des extensions d’indication
#BigPharma ayant (encore) besoin de #RCT avec des résultats favorables pour obtenir l'#AMM de nouveaux produits ou des extensions d’indication
