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Thrilled to share our latest work, now in @ScienceMagazine! Exploring how #3DGenome organization controls #transcription dynamics during #development. A few highlights below! #InHoxWeTrust
@XinyangBing
Zachary Sisco
@J_Raimundo_
@Michal_Levo
Mike Levine
science.org/doi/10.1126/sc…
@XinyangBing
Zachary Sisco
@J_Raimundo_
@Michal_Levo
Mike Levine
science.org/doi/10.1126/sc…
The Drosophila genome is organized by 2 types of elements: tethers mediate focal contacts, while insulators establish #TAD boundaries. We used genome editing and live transcription imaging to explore their roles in the temporal regulation of #Hox gene expression in the embryo. 
Transcription of the endogenous Scr gene, live! Active transcription foci (white spots) appear in a narrow stripe of nuclei (blue) just prior to the onset of gastrulation. (Scr-MS2, MCP-GFP, His2A-RFP)
