Discover and read the best of Twitter Threads about #enhancers
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1/ Excited to share work led by @varshney_arushi genetics.org/content/211/2/… @GeneticsGSA, we compared gene regulatory annotations defined using diverse #epigenomic data across 4 cell types to measure cell specificities and #genetics of #geneRegulation 
2/ We observed that stretch and super #enhancers are more cell type-specific whereas HOT regions and broad domains comprise more ubiquitous promoter states
3/ #eQTL in stretch enhancers have significantly smaller effect sizes compared to those in HOT regions. This suggests regulatory buffering where the expression of cell-identity genes is more tightly controlled
