Discover and read the best of Twitter Threads about #epigenetics

Most recents (16)

🚗 Little Red Corvette 🚗

"It remains unknown whether Epigenetic Age Acceleration (EAA) within an individual shows strong correlation between different primary tissue sites, the extent to which tissue pathology and clinical illness correlates with EAA in the target organ...>
Epigenetic age was moderately correlated across tissues. BLOOD HAD THE GREATEST NUMBER AND DEGREE OF CORRELATION, MOST NOTABLY WITH SPLEEN AND BONE MARROW...>
HIV INFECTION WAS ASSOCIATED WITH POSITIVE AGE ACCELERATION in kidney and spleen...greater multimorbidity was associated with greater EAA across all tissues.">
biorxiv.org/content/10.110…
Read 5 tweets
In 2021 the world celebrated the 100th anniversary of the discovery of #insulin surely one of the greatest medical breakthroughs of the 20th century #diabetes #T1D @NobelPrize @uoftmedicine academic.oup.com/edrv/article-a…
#EndcrineReviews was pleased to publish a collection of articles devoted to advances #T1D #insulin #diabetes #islets A brief recap, here a comprehensive look at the human islet @powersac_TN @MouseCentral academic.oup.com/edrv/article-a…
A comprehensive deep dive into the human β-cell from autoimmunity to secretory function, proliferation, growth, ER stress and biomarkers. @BruceVerchere @StevenKahn11 academic.oup.com/edrv/article/4…
Read 8 tweets
Picking up where @rita_rebollo left, we spent a couple of years annotating and analyzing the rest of the rice #weevil #genome (ok, the 15% left after removing repeats)! All info presented here is on the huge Additional file 2 in @BMCBiology doi.org/10.1186/s12915… 1/n
@VargasChavezC and @gabaldonlab performed a comprehensive #phylogenomic analysis of the rice #weevil and found that this insect has a high gene expansion rate when compared to other beetles. 2/n Image
With the invaluable help of the SymT group from @INRAE_UMR_BF2I we have also reconstructed the #metabolic pathways from both #symbiotic partners. Specific losses of enzymes in the #weevil genome are limited while its #endosymbiont has suffered much more degradation. 3/n
Read 13 tweets
#Epigenetics

An Introduction to Epigenetics
1/ Epigenetics means on top of genetics. The study of Genetics is all about the DNA. Its about how its structured and packaged. Epigenetics is about how Genes are expressed and regulated.
2/ We are born with our Genetics, but our Epigenetics is acquired by experiences and environmental exposure. I don't want to get too deep into epigenetics, but I think there are a few concepts that are important to understand.
Read 14 tweets
As short-read #sequencing (SRS) costs begin to drop again, undoubtedly fueled by a resurgence in competition, I suspect many liquid biopsy providers will add blood-based whole-genome sequencing (WGS) to supplement, or replace, the deep targeted sequencing paradigm.
With a few exceptions, most clinical-stage diagnostic companies build patient-specific panels by sequencing the solid tumor, then downselecting to a few dozen mutations to survey in the bloodstream.

I don't think this approach is going anywhere anytime soon.
However useful, this deep-sequencing approach suffers from several challenges:

1. It requires access to tissue.
2. It requires the construction of patient-specific PCR panels.
3. It requires significant over-sequencing ($$$).
4. It introduces a third layer of error (PCR).
Read 14 tweets
It is very important in this period of humanity to take a serious look at what is happening in the world friends.

Watch this video first in its entirety & reflect upon current situations critically.

🙏

odysee.com/@AfterSkool:7/…
#Menticide is here & with it, a new attempt to establish a "#TechnoTotalitarian" rule over the lives of American citizens.

The final variant of #Coronavirus could very well be the manifestation of a #NewWorldOrder under #totalitarian rule.
That may sound absurd, but what is very concerning is that many talking heads in the media & even public figures are now making very carefully worded emotional appeals to logic to further induce a totalitarian #masspsychosis.
Read 53 tweets
@Twitter Você conhece sobre o Ensaio de Valor de Cultivo e Uso? Vem conferir essa thread ->
Os programas de melhoramento objetivam o desenvolvimento de cultivares superiores às atuais, através de diversos métodos e avaliações. Para o lançamento de cultivares no mercado, o Ministério da Agricultura, Pecuária e Abastecimento (MAPA) estabelece mecanismos
para organizar, sistematizar e controlar a produção e comercialização de sementes e mudas através do Registro Nacional de Cultivares (RNC). Este registro visa habilitar cultivares e espécies de quaisquer grupos para a produção e comercialização,
Read 16 tweets
I reviewed quite a few reproductive #epigenetics papers over the last several years and I find myself saying the same things over and over. So a thread 🧵 on things to consider and important information to include in your manuscript 1/

@OpenAcademics @AcademicChatter #phdchat
Cite the software you use and the version number! People work hard to make those tools available and they deserve the credit 2/
The work should be reproducible. I can write an entire thread on this alone but check out our paper in @FEBS_Letters here - febs.onlinelibrary.wiley.com/doi/full/10.10… 3/
Read 12 tweets
What your are thinking right now is having an impact on your genetic expression and in turn your health. What you are feeling right now is having an impact on your genetic expression and in turn your health.
What emotion you are going through right now is having and impact on your genetic expression and in turn your health.
Your thoughts, feelings and emotions impact your biology! If your emotions can bring such a physical and mental change in you, you now know how it’s impacting your genes at a cellular level too! When they say genetic most people give up like there is nothing to do.
Read 7 tweets
Proud to share our new paper!! We explored recent evidence on #epigenetics #transposons and #population #genetics to look beyond the two-speed genome evolution model!! @OggenfussUrsula @danielcroll @MFSeidl sciencedirect.com/science/articl…
Genomic compartments specifically benefit plant pathogen lifestyle? Well... genomic compartments occur all across the tree of life @OggenfussUrsula @MFSeidl @danielcroll Image
Then, they are a consequence of #transposon insertions and accumulation? Or a consequence of #chromatin organization? Probably both! @OggenfussUrsula @danielcroll @MFSeidl Image
Read 3 tweets
So many people are curious about their genes. These same people might get curious about their “true biological age” and companies are happy to take their money. I just wrote about it. Here’s what I found. THREAD. Image
23andMe has become the “Kleenex” of the direct-to-consumer genetic testing world. It’s short-hand for the type of product itself. You spit and get back a report about your genetic risk for cardiovascular disease, for hating the taste of cilantro and for having a unibrow.
But there’s a new tide rising: direct-to-consumer EPIGENETIC kits. Already a few companies are offering these very expensive saliva/blood/urine kits ($300-700 US) to give you tailored reports on how your body is truly aging and what to do about it.
Read 13 tweets
🥳 We are celebrating 1 year of @ECHO_ERCproject 🤩

Started on 1st of March 2019, the project lead by Alberto Palloni has as the main objective to reformulate and generalize standard theories of human #health and #mortality.
💶: @ERC_Research 🇪🇺
🗓️: 5 years
#epidemiology #ERC
@ERC_Research @sebadaza @lauracilek @mathiasvoigt2 @Demografia_CSIC @CCHS_CSIC @Europeos_CSIC @REA_research @dordanovich During year 1, Alberto Palloni has:
-moved from @UWSoc 🇺🇸 ✈️ to @CSIC 🇪🇸
-set his own team of researchers and collaborators, specialised in #sociology, #demography, #geography, #epidemiology and #epigenetics👩🏽‍💻🧑🏻‍💼👨🏾‍💻👩‍🔬
-identified suitable health #databases & #longitudinal studies
@ERC_Research @sebadaza @lauracilek @mathiasvoigt2 @Demografia_CSIC @CCHS_CSIC @Europeos_CSIC @REA_research @dordanovich @UWSoc @CSIC @IEGD_CSIC Meet Alberto's team at @CCHS_CSIC!
-Diego Ramiro: Director of @IEGD_CSIC @Demografia_CSIC
-Sebastián Daza: Demographer and Social Data Scientist @sebadaza
-Mathias Voigt: Demographer @mathiasvoigt2
-Dariya Ordanovich: Geographer, GIS Specialist and Data Scientist @dordanovich
Read 9 tweets
1/ New insights into control of #tregs by #DNAmethylation from #SingerLab. #epigenetics @luisamnMD @NMPulmCritCare

Check out our new preprint on @biorxivpreprint: biorxiv.org/cgi/content/sh…
2/ Treg cells are known to require a lineage-specific DNA hypomethylation pattern during development that stabilizes their lineage. We wanted to determine whether maintenance DNA methylation is required for Treg cell lineage development and stability.
3/ Accordingly, we bred mice with Treg cell-specific deficiency in the epigenetic regulator Uhrf1, which maintains methyl-DNA marks. These mice displayed a profound inflammatory phenotype.
Read 13 tweets
Today we launch the @ECHO_ERCproject online!🥳
ECHO is lead by Alberto Palloni & financed by the @ERC_Research #H2020 programme🇪🇺
The project started on March 2019 and will run until 2024, hosted at the Institute of Economy,Geography and Demography of @CCHS_CSIC #Madrid
#research
@ERC_Research @CCHS_CSIC What we want to do?🧐
👉🏾 reformulate and generalize standard theories of human #health and #mortality
👉🏾propose new formal models and a systematic agenda to empirically test hypotheses that link developmental #biology, #epigenetics and adult human illness, #disability mortality.
@ERC_Research @CCHS_CSIC Together with Alberto Palloni, the team is joined by demographers, geographers and technicians:
echo-erc.csic.es/echo-team/

The more, the better! @ECHO_ERCproject also collaborates with other scientists who provide knowledge and expertise to achieve the ambitious research programme
Read 6 tweets
Andy Feinberg has written a review about #epigenetics in @NEJM.

Unfortunately, it’s damaging to the field of human epigenetics research.

The Key Role of Epigenetics in Human Disease Prevention and Mitigation
nejm.org/doi/full/10.10…
A couple of historical inaccuracies to start. Waddington was saying the opposite – cell fate (the cellular event in epigenesis) is probabilistic, not deterministic. The major point he was making was that genes have a role in influencing epigenesis, a major argument at the time
Waddington did not ignore environment at all. In fact, he treated Drosophila larvae with heat/ether to see whether he could influence cell fate. He considered the epigenetic landscape (cell fate) potentially modifiable by environment and genetic variation, see next image
Read 13 tweets
I wasn’t really expecting this tweet to get such a response. It clearly hit a communal nerve. Probably in part because I was deliberately provocative 1/
2/ Did @ryanlisterlab really show that DNA methylation has no role in transcriptional repression? Of course not. But they do show that it does not seem to be enough by itself to change the expression of genes
3/ Why is that observation important? Because it makes us think a bit more critically about something that plagues #epigenome-wide association studies, the idea that environment changes DNA methylation, gene expression and cellular memory.
Read 10 tweets

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