Discover and read the best of Twitter Threads about #estimand
Most recents (1)
1/n
Clinical trials in patients with hematological malignancies often present unique challenges for trial design due to complexity of tmt options and existence of potential curative but highly risky procedures, for example, SCT or tmt sequence across different phases.
Clinical trials in patients with hematological malignancies often present unique challenges for trial design due to complexity of tmt options and existence of potential curative but highly risky procedures, for example, SCT or tmt sequence across different phases.
2/n
I am very happy to see our paper
Estimands in hematologic oncology trials
now online at Pharm Stat: doi.org/10.1002/pst.21…
The paper illustrates how to apply the estimand framework in hematological clinical trials and how the estimand framework can address...
I am very happy to see our paper
Estimands in hematologic oncology trials
now online at Pharm Stat: doi.org/10.1002/pst.21…
The paper illustrates how to apply the estimand framework in hematological clinical trials and how the estimand framework can address...
3/n
... potential difficulties in trial result interpretation. Three phase 3 RCTs are used to illustrate different scientific questions and the consequences of the estimand choice for
- trial design,
- data collection,
- analysis,
- and interpretation.
... potential difficulties in trial result interpretation. Three phase 3 RCTs are used to illustrate different scientific questions and the consequences of the estimand choice for
- trial design,
- data collection,
- analysis,
- and interpretation.
