Discover and read the best of Twitter Threads about #evd68
Most recents (3)
Huge thanks to @HopkinsMedicine @AmaryFaln @hmostaf2 for sending along the first #Enterovirus #D68 #EVD68 sequences of 2022! 🙏🏻🚀
You can see them in the full-genome & VP1 builds:
nextstrain.org/enterovirus/d6…
nextstrain.org/enterovirus/d6…
1/5
You can see them in the full-genome & VP1 builds:
nextstrain.org/enterovirus/d6…
nextstrain.org/enterovirus/d6…
1/5
Note that for the moment I don't have anything but year for these sequences, so month is being inferred by the pipeline - note the wide confidence interval on the date!
However, zooming into the VP1 build, we can see some interesting connections...
2/5
However, zooming into the VP1 build, we can see some interesting connections...
2/5
All part of the B3 clade, 1 seq attaches to autumn 2021 circulation in Europe/USA (1), 1 attaches back to European circulation in autumn 2019 (2), and the rest attach back to USA+ circulation in autumn 2019 (3).
3/5
3/5
📡#Enterovirus #D68 #EVD68 builds on @nextstrain are now updated 📡
You can check out the VP1 (single-gene) build (nextstrain.org/enterovirus/d6…) & full-genome builds (nextstrain.org/enterovirus/d6…).
I'll give a brief overview of a few things of interest...
1/7
You can check out the VP1 (single-gene) build (nextstrain.org/enterovirus/d6…) & full-genome builds (nextstrain.org/enterovirus/d6…).
I'll give a brief overview of a few things of interest...
1/7
The VP1 #EVD68 build lets us include the most sequences, so I'll focus on that here - though full-genome has many other advantages!
No 2022 seqs yet (got my 👁️peeled!), but there are some from 2021 - from Europe & N America. These stem from the B3 & A2 clades.
2/7
No 2022 seqs yet (got my 👁️peeled!), but there are some from 2021 - from Europe & N America. These stem from the B3 & A2 clades.
2/7
And more specifically, are related to seq clusters that circulated in 2018/2019.
Huge thanks to @HopkinsMedicine @AmaryFaln @NIBSC_MHRA Javier Martin, Alison Tedcastle @UKL_Leipzig Mario Hönemann @CHUDijon Alexis de Rougemont, Isabelle Schuffenecker & more for these seqs!
3/7
Huge thanks to @HopkinsMedicine @AmaryFaln @NIBSC_MHRA Javier Martin, Alison Tedcastle @UKL_Leipzig Mario Hönemann @CHUDijon Alexis de Rougemont, Isabelle Schuffenecker & more for these seqs!
3/7
Recently I've heard from collaborators in the US & Europe that #Enterovirus #D68 #EVD68 cases are on the rise.
EV-D68 is what I worked on pre-pandemic, & hope to go back to.
A significant autumn 2022 wave has been a recent concern.
So what is D68 & what might this mean?
1/17
EV-D68 is what I worked on pre-pandemic, & hope to go back to.
A significant autumn 2022 wave has been a recent concern.
So what is D68 & what might this mean?
1/17
#EVD68 is a Picornavirus - a diverse family of viruses. And Enteroviruses are pretty diverse themselves: from Poliovirus, which can cause serious neurological illness, to Rhinovirus - what's behind the common cold 🤧 (and even more in between).
2/17
2/17
One of the most notable things about #EVD68 is that in Europe & North America it's historically had biennial autumn outbreaks: in 2014, 2016, & 2018. Also predicted in 2020... but that didn't happen due to pandemic!
Following that pattern, 2022 would be an outbreak season🗓️
3/17
Following that pattern, 2022 would be an outbreak season🗓️
3/17
