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#NARCAN Nasal Spray would be vastly more affordable/accessible if we acknowledged that 1 dose per kit is sufficient. Comparing plasma #naloxone concentrations following administration of various doses by intranasal (IN) & intramuscular (IM) routes tells us a lot. THREAD
Consider this graph from #NARCAN prescribing info (ignore top 2 lines). 0.4mg IM (vial+syringe) achieves lowest peak level...but it still works & has saved countless lives. 2mg IN (prefilled+MAD) achieves higher peak, & 4mg IN (NARCAN) achieves highest peak.
Follow concentration x6 hours...level of #naloxone in circulation 3 hours after receiving #NARCAN 4mg IN is higher than peak level after 0.4mg IM. Based on this data, it is reasonable to assert that NARCAN is effective for much longer than 30-90 minutes.
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