Discover and read the best of Twitter Threads about #exhaustion
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Delighted to share our paper, biorxiv.org/content/10.110… . Huge thanks to @CoukosGeorge for the opportunity as well as all our collaborators, @carmonation. A summary of our main findings:
Orthogonal combinatorial T-cell engineering overcomes homeostatic barriers to engraftment, reprograms TILs as well as the tumor microenvironment and mediates solid tumor regression in the absence of preconditioning or systemic cytokine support @CoukosGeorge, @carmonation
As a proof of principle of orthogonal T-cell engineering, here we successfully combined two main secreted components: an IL-2 variant binding to b/g but not IL-2Ra (promote T-cell stemness), together with the pro-inflammatory alarmin IL-33.
World Economic Forum: "Lockdown is the world's biggest #psychological #experiment - & we will pay the price"
Apr 9 2020 "With some 2.6 billion people around the world in some kind of #lockdown, we are conducting arguably the largest psychological experiment ever"
#Conditioning
Apr 9 2020 "With some 2.6 billion people around the world in some kind of #lockdown, we are conducting arguably the largest psychological experiment ever"
#Conditioning
"Unfortunately, we already have a good idea of its results. In late Feb 2020, right before EU countries mandated various forms of lockdowns, The Lancet published a review of 24 studies documenting the #psychological impact of quarantine."
#Handy
#Handy
"The findings offer a glimpse of what is brewing in hundreds of millions of households around the world...
people who are #quarantined are very likely to develop a wide range of symptoms of #psychological #stress and #disorder..."
#Conditioning
people who are #quarantined are very likely to develop a wide range of symptoms of #psychological #stress and #disorder..."
#Conditioning
001/ [article content in this tweet series 001-180 reproduced with permission from Martin Howe QC of Lawyers for Britain @lawyers4britain]
#quote "Leaving the EU on WTO terms: pulling down the barriers to world trade
Introduction: why prices will FALL after Brexit, not rise" /002
#quote "Leaving the EU on WTO terms: pulling down the barriers to world trade
Introduction: why prices will FALL after Brexit, not rise" /002
002/ #quote "Over the past couple of weeks, the media have been full of lurid scare stories about what will happen if the UK leaves the EU on WTO terms, because negotiations with the EU do not result in a withdrawal agreement." /003
#tariffs #NoDeal #Brexit #WTO #ProjectFear #shortages #food #medicines
003/ #quote "One of the most ridiculous and UNJUSTIFIED of these absurd scare stories is that it will lead to higher prices, and even shortages, of foods and medicines." /004
003/ #quote "One of the most ridiculous and UNJUSTIFIED of these absurd scare stories is that it will lead to higher prices, and even shortages, of foods and medicines." /004
