Discover and read the best of Twitter Threads about #factorial

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We are all being rightly encouraged to be #efficient in our trial design & conduct. Efficiency comes primarily through design choices … whether classic or more modern efficient designs … a few reflections below 1/7
#MethodologyMonday
A #crossover design can be highly efficient. Each person acts as their own control removing large element of variation, making the design more powerful. The outcome needs to be short term however & the intervention can’t have a long-standing effect 2/7
bmj.com/content/316/71… Image
This is particularly the case when a cluster design is also in play. A #ClusterCrossover design can majorly reduce the sample size requirements compared with a std cluster design. A good primer on this was published by @karlahemming and colleagues 3/7
bmj.com/content/371/bm… ImageImage
Read 7 tweets
Si hay una pregunta clave en combinatoria es ¿cuántos/as…? La combinatoria trata de contar el número de configuraciones distintas que se pueden formar con los elementos de un conjunto. Así, criterios como el orden y la posibilidad de repetición son cruciales.

Dentro hilo ⬇️⬇️
Por ejemplo, dado un conjunto de siete letras distintas...

¿De cuántas formas se pueden ordenar? ¿Cuántas palabras de cuatro letras se pueden formar (tengan o no sentido)? ¿De cuántas formas se pueden escoger tres de ellas?
A fin de encontrar respuestas, debemos prestar atención a:

a) Los elementos de que disponemos.
b) Los elementos que debe contener cada grupo.
c) La posibilidad (o no) de repetir elementos.
d) La importancia o indiferencia en cuanto al orden en que aparecen los elementos.
Read 39 tweets

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