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Excited to share our work on how antibodies are produced during SARS-CoV-2 infection! biorxiv.org/content/10.110… A brief summary... (1/n)
While protective antibody responses usually depend on T follicular helper (Tfh) cells, impaired Tfh responses have been observed in severe COVID-19: doi.org/10.1016/j.cell… We were therefore curious how this would affect antibody production to SARS-CoV-2. (2/n)
We infected mice lacking Tfh cells (Bcl6fl/fl;Cd4Cre) or all CD4+ T cells (Ciita-/-) with SARS-CoV-2. While most spike-specific IgG antibodies required CD4+ T cell help, substantial levels of these antibodies could be made in the absence of Tfh cells. (3/n)
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