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1/ 📢Hello #MedTwitter
Let’s talk about pediatric #MPGN / ‘Immune complex GN’ #ICGN today
A few pearls from the 1st @ASPNeph pathology webinar of 2021
#tweetorial #NephTwitter
Let's begin with a poll:
❓Which of the following is true about IC-MPGN?
Let’s talk about pediatric #MPGN / ‘Immune complex GN’ #ICGN today
A few pearls from the 1st @ASPNeph pathology webinar of 2021
#tweetorial #NephTwitter
Let's begin with a poll:
❓Which of the following is true about IC-MPGN?
2/ All the above
⚡️There is limited data on epidemiology
⚡️The estimated prevalence is 1 to 2/ million children, 5 to 15 years of age
⚡️There is limited data on epidemiology
⚡️The estimated prevalence is 1 to 2/ million children, 5 to 15 years of age
3/💥MPGN denotes “pattern of injury” not etiology
⚡️Characteristic mesangial & endocapillary cellularity
⚡️Thickening of glomerular capillary walls due to subendothelial deposition of IC/complement factors
⚡️Characteristic mesangial & endocapillary cellularity
⚡️Thickening of glomerular capillary walls due to subendothelial deposition of IC/complement factors
1/ 📢Hello #MedTwitter
We recently had an interesting case-based discussion @ASPNeph pathology webinar.
Here’s what I learned about💥Rhabdomyolysis💥(RM) and AKI!
Let's begin with a poll:
Which one of these is true about RM?
#tweetorial #NephTwitter
We recently had an interesting case-based discussion @ASPNeph pathology webinar.
Here’s what I learned about💥Rhabdomyolysis💥(RM) and AKI!
Let's begin with a poll:
Which one of these is true about RM?
#tweetorial #NephTwitter
2/ Ans: All the above.
💥Rhabdomyolysis💥
The disintegration of skeletal muscle→ release of intracellular constituents (myoglobin, electrolytes & Uric acid) into ECF & circulation
💥Rhabdomyolysis💥
The disintegration of skeletal muscle→ release of intracellular constituents (myoglobin, electrolytes & Uric acid) into ECF & circulation
3/Let’s review 💥pathophysiology💥:
📌Myoglobinemia→ intrarenal vasoconstriction→ direct and ischemic tubule injury
📌Myoglobinuria→ cast formation & tubular obstruction→ cast nephropathy
nejm.org/doi/10.1056/NE…
📌Myoglobinemia→ intrarenal vasoconstriction→ direct and ischemic tubule injury
📌Myoglobinuria→ cast formation & tubular obstruction→ cast nephropathy
nejm.org/doi/10.1056/NE…
