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This one provides genetically proxied evidence to support that FGF21 signaling may reduce chronic kidney disease risk, have favorable effects across a broad range of renal outcomes and cardiometabolic risk factors. 
- Fibroblast growth factor 21 (FGF21) is a fasting or stress inducible metabolic hormone produced mainly in the liver.
It plays important roles in regulating glucose and lipid homeostasis, as well as bone homeostasis.
It plays important roles in regulating glucose and lipid homeostasis, as well as bone homeostasis.
- This study leveraged a missense genetic variant, rs739320 in the FGF21 gene, that associates with magnetic resonance imaging-derived liver fat as a clinically validated and biologically plausible instrumental variable for studying the effects of FGF21 analogs.
