Discover and read the best of Twitter Threads about #fluvoxamine
Most recents (19)
#Metformin RCT on 41% prevention of #LongCOVID with acute #COVID19 treatment is now published in @TheLancetInfDis at:
doi.org/10.1016/S1473-…
N=1126 with long term follow up (~5% lost by 9mo)
10.4% vs. 6.3% LC incidence.
Double blind RCT using identical matched placebo.
Cost $1
doi.org/10.1016/S1473-…
N=1126 with long term follow up (~5% lost by 9mo)
10.4% vs. 6.3% LC incidence.
Double blind RCT using identical matched placebo.
Cost $1
The distribution of symptoms reported over time was similar as others have found. The figure (a new additional from the original pre-print) displays the freq of symptoms reported over 9 months among those wih a long covid diagnosis vs. no diagnosis.
#LongCovid symptoms interfered with both the ability to work and affected leisure activities in about half of those with LC. This very, very slowly decreased over time.
Metformin's benefit for #COVID19 is from an anti-viral effect.
3.6-fold greater reduction in #SARSCOV2 viral load over placebo equating to: -0.56 log10 copies/mL (95%CI, -1.05 to -0.06,p=0.027) #IDTwitter
medrxiv.org/content/10.110…
3.6-fold greater reduction in #SARSCOV2 viral load over placebo equating to: -0.56 log10 copies/mL (95%CI, -1.05 to -0.06,p=0.027) #IDTwitter
medrxiv.org/content/10.110…
We observed no virologic effect of #ivermectin at median of 430 mcg/kg/day x3 days or of low-dose #fluvoxamine at 50mg 2x/d.
Metformin Virologic Effect was generally consistent across subgroups, larger in the unvaccinated at -0.773 log10 copies/mL (95%CI, -1.408 to -.139)
Metformin Virologic Effect was generally consistent across subgroups, larger in the unvaccinated at -0.773 log10 copies/mL (95%CI, -1.408 to -.139)
Metformin is a $1 therapy.
At Day 5 antiviral effect over placebo was 0.47 log10 copies/mL for metformin, 0.30 log10 copies/mL for molnupiravir, & 0.80 log10 copies/mL for nirmatrelvir; and at Day 10 was 0.64 log10 copies/mL for metformin and 0.35 log10 copies/mL for nirmatrelvir
At Day 5 antiviral effect over placebo was 0.47 log10 copies/mL for metformin, 0.30 log10 copies/mL for molnupiravir, & 0.80 log10 copies/mL for nirmatrelvir; and at Day 10 was 0.64 log10 copies/mL for metformin and 0.35 log10 copies/mL for nirmatrelvir
Another confirmatory trial of beneficial effect of #fluvoxamine 100mg BID with Budesonide inhaler in a highly vaccinated population for #COVID19
Dose matters. 50mg 2x/d is not 100mg 2x/d. FLV 50mg 2x/d did not have benefit in two trials
Dose matters. 50mg 2x/d is not 100mg 2x/d. FLV 50mg 2x/d did not have benefit in two trials
As a combo blinded trial (FLV + inhaler), which one had benefit? Hard to know. In activ-6, we did not observe a benefit of inhaled fluticasone in a double blind RCT, yet UK Principle did see a benefit in open label trial with budesonide.
Importantly the #fluvoxamine dose studied here was 100mg 2x/day.
Covid-out and activ-6 both confirmed a lack of benefit of 50mg 2x/day dose.
If I gave someone 1/2 the effective dose of an HIV med & it didn't work, does that mean the med doesn't work? Or just dose was wrong?
Covid-out and activ-6 both confirmed a lack of benefit of 50mg 2x/day dose.
If I gave someone 1/2 the effective dose of an HIV med & it didn't work, does that mean the med doesn't work? Or just dose was wrong?
1/ Après #hydroxychloroquine #fluvoxamine #ivermectine #IEC #paxlovid => l'anticorps contre la COVID-19 #evusheld !
La pandémie de biais temporels immortels continue...
La pandémie de biais temporels immortels continue...
2/Aujourd'hui nous publions dans @CIDJournal
une lettre sur une nouvelle étude observationnelle de l'anticorps covid-19 tixagevimab/cilgavimab #Evusheld.
👇
academic.oup.com/cid/advance-ar…
une lettre sur une nouvelle étude observationnelle de l'anticorps covid-19 tixagevimab/cilgavimab #Evusheld.
👇
academic.oup.com/cid/advance-ar…
3/ Cette étude de cohorte rapporte une diminution du risque d'infarctus du myocarde, d'arythmie ou d'insuffisance cardiaque dans les 30 jours suivant le traitement par tixagevimab/cilgavimab par rapport à la cohorte témoin (risque relatif : 0,84, 0,93, 0,89).
1/ After #hydroxychloroquine #fluvoxamine, #paxlovid = #evusheld !
The pandemic of immortal time bias continues...
@drjohnm @venkmurthy @VPrasadMDMPH @TracyBethHoeg
The pandemic of immortal time bias continues...
@drjohnm @venkmurthy @VPrasadMDMPH @TracyBethHoeg
2/Today we publish in @CIDJournal a letter on a new observational study of the covid-19 antibody tixagevimab/cilgavimab #Evusheld
👇
academic.oup.com/cid/advance-ar…
@VPrasadMDMPH
👇
academic.oup.com/cid/advance-ar…
@VPrasadMDMPH
3/ The cohort study reporting an decrease risk of myocardial infarction, arrhythmia or heart failure in the 30 days after treatment by tixagevimab/cilgavimab compared to the control cohort (relative risk : 0.84, 0.93, 0.89)
COVID-Out double-blind randomized trial tested #metformin, ivermectin, or fluvoxamine for outpatient #COVID19. Secondary endpoint was incidence of Long Covid (PASC).
Volunteers were followed monthly to 10 mo.
Metformin 42% reduction in Long Covid.
medrxiv.org/content/10.110…
Volunteers were followed monthly to 10 mo.
Metformin 42% reduction in Long Covid.
medrxiv.org/content/10.110…
Incidence of Healthcare provider diagnosed long covid (PASC) was 42% less among those randomized to #metformin vs. matched placebo.
Hazard Ratio for Long Covid in the metformin group versus control was 0.58 (95% CI 0.38 to 0.88, P=0.009);
Hazard Ratio for Long Covid in the metformin group versus control was 0.58 (95% CI 0.38 to 0.88, P=0.009);
There was no benefit for those randomized to #ivermectin vs. matched placebo for reducing long covid and low-dose #fluvoxamine was not beneficial either for decreasing #longcovid.
1/ I'm approaching my 2 year anniversary of #LongCovid . I thought I would share my journey to recovery. This is not medical advice, just my story. If it helps one person it's worth it. I learned more from Twitter than anywhere else on this journey. #microclots #teamclots #pots
2/ I got COVID November 2020. Night 1 I had the most excruciating headache of my life. It felt as if someone was drilling into my forehead. The headache dissipated after 2 days only to return day 13. Initially I had some minor brain fog, like putting Ice Cream in the fridge etc
3/ I never lost my sense of taste or smell. I had a minor fever/body aches for 24 hours. Day 4, I started having heart rate issues. I would be resting on the couch and get up to walk to the bathroom and my heart rate would jump to 130.
Mars 2022 : l’OMS rejette la #Fluvoxamine mais recommande le #Molnupiravir de Merck, un traitement décrit comme une « pilule miracle » (BFMTV*).
Octobre 2022 : un essai randomisé sur 25,783 patients** (PANORAMIC) montre que le médicament n’a pas d’effet sur les hospis ou décès.
Octobre 2022 : un essai randomisé sur 25,783 patients** (PANORAMIC) montre que le médicament n’a pas d’effet sur les hospis ou décès.
*Source : google.com/amp/s/www.bfmt…
** Source PANORAMIC : papers.ssrn.com/sol3/papers.cf…
Je suis entrain de regarder l'avis qu'a produit le HSCP en 2018 pour recommander le Tamiflu (Gilead) contre la grippe...
👉🏼 Le Tamiflu ne réduit pas les hospis pour grippe en RCT : recommandé.
👉🏼 La #Fluvoxamine réduit les hospis pour COVID-19 en RCT : rejeté.
Étonnant, hein ?
👉🏼 Le Tamiflu ne réduit pas les hospis pour grippe en RCT : recommandé.
👉🏼 La #Fluvoxamine réduit les hospis pour COVID-19 en RCT : rejeté.
Étonnant, hein ?
Ps : Oseltamivir = Tamiflu.
Ah oui, au cas où ne saviez pas : Gilead était déjà de la partie lors de la grippe H1N1 en 2009 (en partenariat avec Roche). Déjà à l'époque les essais cliniques du médicament étaient assez spéciaux, et ce n'était pas complotiste de le dire.
theguardian.com/business/2014/…
theguardian.com/business/2014/…
Suite à une demande du chercheur Français @HoertelN, @ansm a refusé une autorisation d’utilisation pour la #Fluvoxamine contre #Covid dans un Cadre de Prescription Compassionnelle adaptée aux présomptions d’efficacité
Thread/ qualité du rapport Ansm
ansm.sante.fr/uploads/2022/0…
1/25
Thread/ qualité du rapport Ansm
ansm.sante.fr/uploads/2022/0…
1/25
Contexte de la Fluvo en France:
D’après le dernier livre de @MartinBlachier, le milieu de @APHP a bloqué la recherche sur la #fluvoxamine…
Pourtant @HoertelN y travaille.
Ils ont refusé de grands travaux de recherche.
2/
D’après le dernier livre de @MartinBlachier, le milieu de @APHP a bloqué la recherche sur la #fluvoxamine…
Pourtant @HoertelN y travaille.
Ils ont refusé de grands travaux de recherche.
2/
Puis après une très longue attente (nombreux rdv et félicitations) c’est un #ConseilScientifique très réseauté qui bloque pour que @ansm refuse une évaluation.
Apres un parcours du combattant, @HoertelN parvient enfin à faire évaluer sa demande.
Pourquoi c’est si dur ?
3/
Apres un parcours du combattant, @HoertelN parvient enfin à faire évaluer sa demande.
Pourquoi c’est si dur ?
3/
Plongée dans la sphère de désinformation complotiste.
Oui vous savez, celle où l'#IVM, l'#AZT, le #zinc et les #vitamines sont "portentiellement dangereuses", la #fluvoxamine "manque de preuves", mais où le #molnupiravir et les AC monoclonaux hors de prix sont "efficaces" !
Oui vous savez, celle où l'#IVM, l'#AZT, le #zinc et les #vitamines sont "portentiellement dangereuses", la #fluvoxamine "manque de preuves", mais où le #molnupiravir et les AC monoclonaux hors de prix sont "efficaces" !
Ah ces théories du complot, où ces complotistes de la HAS interdisent le bon vieux molnupiravir, et où l'Académie de Médecine et la Revue du Practicien recommandent la Vitamine D. Et que dire de ces pays corrompus comme l'Inde ou le Japon qui utilisent avec succès l'Ivermectine ?
Cette sphère d'une #bienveillance ... extrême
It’s crushing to hear such outcry abt overwhelmed hospitals knowing early, outpatient treatment would have significantly reduced that burden & saved countless lives.
That so few are talking about this is mind-blowing.
Not prioritizing early treatment was a grievous failure.
That so few are talking about this is mind-blowing.
Not prioritizing early treatment was a grievous failure.
Ignoring benefit of effective cheap, repurposed drugs like #fluvoxamine that slash death rate is a crime that is clearly driven by the push to sell expensive, new patented drugs that aren’t out yet. All pts shld be able to try repurposed drugs that can save them.
In March 2021, @60Minutes did a piece abt the life-saving benefits of #fluvoxamine. What happened to it after that, you ask? @IDSAInfo recommended against its widespread use outside of clinical trials!
WHY AREN’T WE DEMANDING EARLY TREATMENT? They exist! nature.com/articles/d4158…
WHY AREN’T WE DEMANDING EARLY TREATMENT? They exist! nature.com/articles/d4158…
💡WOW—a cheap generic anti-depressant Fluvoxamine that costs just $4 reduced #COVID19 hospitalizations risk by ~30%… or from 16% in placebo to 11% in drug group. It even reduced mortality by 91%! #Fluvoxamine 🧵
2) Because it has already been approved by the FDA for mental health treatment, doctors can begin to prescribe it under certain parameters. The relatively modest cost means it could be highly beneficial in parts of the world with few resources. washingtonpost.com/science/2021/1…
3) The study, published Wednesday in the Lancet journal, found that giving high-risk covid-19 patients fluvoxamine — 100 mg twice daily for 10 days — early in their treatment reduced the need for hospitalization. thelancet.com/journals/langl…
🚨BREAKING: #Fluvoxamine—a cheap drug for #depression and obsessive-compulsive disorder—reduced the need for hospitalization among high-risk unvaccinated adults with #COVID19 in a large placebo-controlled randomized study.
apnews.com/article/db6060…
apnews.com/article/db6060…
Among ~1,500 #COVID19 patients in #Brazil randomized for #fluvoxamine or placebo, #fluvoxamine reduced the need for hospitalization or prolonged medical observation by 1/3.
Encouraging results, but please still #GetVaccinated!
#coronavirus #SARSCoV2
google.com/amp/s/www.nyti…
Encouraging results, but please still #GetVaccinated!
#coronavirus #SARSCoV2
google.com/amp/s/www.nyti…
Researchers tested #fluvoxamine because it reduces inflammation, likely blunting the downstream effects of #coronavirus infection.
Several earlier, smaller studies showed promising results, but none was as large or persuasive as this randomized placebo-controlled trial.
Several earlier, smaller studies showed promising results, but none was as large or persuasive as this randomized placebo-controlled trial.
Interesting results from the #TOGETHER RCT of #fluvoxamine vs placebo in n=1497 high risk outpatients in 🇧🇷 with #COVID:
-people who received fluvoxamine were less likely to require extended ED visit or hospitalization (11% vs 16%, RR 0.68 CI 0.52-0.88)
thelancet.com/journals/langl…
1/
-people who received fluvoxamine were less likely to require extended ED visit or hospitalization (11% vs 16%, RR 0.68 CI 0.52-0.88)
thelancet.com/journals/langl…
1/
TOGETHER was a large, multi-arm adaptive platform DB-RCT done in 🇧🇷 Brazil from June 2020 to Jan 2021.
Patients were identified after testing positive, stratified by age (>50 or <50 yo) & randomized to fluvoxamine 100 mg BID x 10 days vs placebo.
2/
Patients were identified after testing positive, stratified by age (>50 or <50 yo) & randomized to fluvoxamine 100 mg BID x 10 days vs placebo.
2/
It builds upon 2 studies:
-an observational study in 🇫🇷 that found better outcomes among inpts already taking SSRIs
nature.com/articles/s4138…
-a small n=152 RCT done in 🇺🇸 showing a decrease in clinical deterioration among outpts randomized to Fluvoxamine
jamanetwork.com/journals/jama/…
3/
-an observational study in 🇫🇷 that found better outcomes among inpts already taking SSRIs
nature.com/articles/s4138…
-a small n=152 RCT done in 🇺🇸 showing a decrease in clinical deterioration among outpts randomized to Fluvoxamine
jamanetwork.com/journals/jama/…
3/
#Fluvoxamine : nouvel espoir de traitement #COVID19 ?
preprint...on va attendre la review mais que peut on dire déjà
…8-4f9a-ae29-44e0df5347d5.filesusr.com/ugd/4e5c71_cc1…
Etude randomisée forte dose/placebo >700 par traitement
Effet sur un critère composite passage >6h aux urgences/hospitalisation
1/5⬇️
preprint...on va attendre la review mais que peut on dire déjà
…8-4f9a-ae29-44e0df5347d5.filesusr.com/ugd/4e5c71_cc1…
Etude randomisée forte dose/placebo >700 par traitement
Effet sur un critère composite passage >6h aux urgences/hospitalisation
1/5⬇️
Le critère passage >6h aux urgence tire l'effet (OR 0,19; p<0,01) alors que l'effet sur hospitalisation n'est pas significatif (OR 0,79; p=0,17)
On va plus vite aux urgences avec la fluvoxamine (OR 0,19; p<0,01) mais moins longtemps ... il faut comprendre pourquoi
2/5⬇️
On va plus vite aux urgences avec la fluvoxamine (OR 0,19; p<0,01) mais moins longtemps ... il faut comprendre pourquoi
2/5⬇️
Pas d'effet sur le passage en réanimation et la mortalité
On peut discuter le manque de puissance mais alors discuter que la durée d'hospitalisation va dans l'autre sens non significatif non plus
Pas d'effet antiviral c'est réglé
3/5⬇️
On peut discuter le manque de puissance mais alors discuter que la durée d'hospitalisation va dans l'autre sens non significatif non plus
Pas d'effet antiviral c'est réglé
3/5⬇️
🚨Interim results of @TogetherTrial of ivermectin and fluvoxamine for early treatment of #COVID_19 🚨
#ivermectin : no significant effect
#fluvoxamine: ↘️ risk of hospitalization by 31%
These important results deserve a🧵 1/n rethinkingclinicaltrials.org/news/august-6-…
#ivermectin : no significant effect
#fluvoxamine: ↘️ risk of hospitalization by 31%
These important results deserve a🧵 1/n rethinkingclinicaltrials.org/news/august-6-…
Trial took place in 10 sites in Minas Gerais, 🇧🇷. 2/n
Patients with early #COVID_19 (e.g. <7days after onset of symptoms) and at least one risk factor were enrolled. 3/n
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%.
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies.
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed.
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues.
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin.
