Discover and read the best of Twitter Threads about #fmd

Most recents (2)

Unido al hilo de Luís sobre la diferenciación de los #macrófagos (M), he considerado oportuno aportar diferentes ESTRATEGIAS NO FARMACOLÓGICAS para hackear la entrada de #glucosa en la célula y evitar su proliferación.

Dentro hilo #inmunometabolismo ⬇️
1️⃣ Inhibir #PDK-1.

Como no quiero aportar fármacos para ello, tocaría saltármela.

¿Cómo? Fácil, cambiando de sustrato. La glucosa pasa por ella. La grasa, no.

PDK-1 es clave en el metabolismo de la glucosa y en la diferenciación de los M. Su caída disminuye M1 y aumenta M2.
En la #mitocondria es el lugar donde se generan los estímulos apópticos.

El daño mitocondrial (metabolismo ineficiente) precede a las neoplasias y estimulan la autoinmunidad.

Aportar nutrientes que estabilicen la biogenesis mitocondrial será clave.
Read 9 tweets
Functional Gait disorders ("FGD" for the purpose of this #twittorial) are common and disabling, usually accompanied by other symptoms. FGD are challenging for the non #MovDis physician and it can difficult to determine #inconsistencies and #incongruencies during examination.
2/
A good approach is to identify #clinicalSigns to differentiate a #functional vs #organic cause

#Inconsistency is the variability in gait disorder severity over time.
#incongruency involves a combination of symptoms and sins not seen in organic disorders.
#distractibility
3/
Read 19 tweets

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