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#SubstanceSaturdays ❄️
1/ #Cocaine is a powerful stimulant drug that has been around for thousands of years. It was originally used by indigenous people in South America for religious & medicinal purposes, and was later introduced to Europe and the US in the late 19th century.
1/ #Cocaine is a powerful stimulant drug that has been around for thousands of years. It was originally used by indigenous people in South America for religious & medicinal purposes, and was later introduced to Europe and the US in the late 19th century.
2/ Cocaine works by increasing levels of #dopamine, a neurotransmitter that regulates pleasure and reward, by blocking its reuptake leading to an accumulation in the synpatic cleft. This leads to feelings of euphoria, increased energy and alertness, and decreased appetite.
3/ Serotonin and norepinehphrine reuptake are also inhibited, leading to increases in those neurotransmitters as well. Sodium channels are also blocked, slowing down the action potentials, thus leading to its medical use as a local anesthetic.
