Discover and read the best of Twitter Threads about #fracturefriday

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A dream came true!! Our paper: "Neutrophil-derived catecholamines mediate negative stress effects on bone" is now published in @NatureComms 🎉

This work is a joint project from my group at @OrthoLabUlm & @MolPsySoUlm! A fantastic cross-discipline collaboration!

A thread: Image
We found out earlier that chronic psychosocial stress during adulthood disturbs long bone growth and fracture healing in mice: doi.org/10.1073/pnas.1…

But the question was: what is the mechanism? We answered that in our latest study. Stress leads to catecholamine production ...
... in local immune cells in the bone marrow and the fracture callus. These catecholamines disturb endochondral ossification via the beta2-adrenoreceptor on chondrocyte-derived cells in mice. Most importantly, we could confirm this also in human samples:

Fracture patients...
Read 7 tweets
Following on from our #Tweetorial looking at silver trauma on this week’s #FractureFriday we’re taking a look at the (grand)mother of all fractures, so important they only take 3 letters to recognise – NOF!!
These patients are so important to manage appropriately as there is a 10% mortality in 30 days and 30% at a year post injury!! The Nottingham hip fracture score helps calculate the individuals risk based on various parameters.
Although these injuries can occur in younger patients as a result of high energy mechanisms the vast majority occur in older patients as a result of low energy injuries.
Read 18 tweets

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