Discover and read the best of Twitter Threads about #gabapentin

Most recents (4)

At the #CPDD22 mini-symposium on #gabapentin talks about considerable research highlighting potential for SUD treatment but also high rates of identification in overdose. Prescribing continues to increase yet diversion appears to trend down after regulatory changes 1/
2/ anecdotal reports of #gabapentin enhancing opioid effects and reducing withdrawal. Motivation for use is a mix of non-medical use with other substances and therapeutic motivations e.g. to self manage pain/withdrawal
3/ increases in gapabentin increase in a linear manner compared with low/stable pregabalin prescribing (interesting this is reversed in Australia) - it is commonly being prescribed off label for substance use treatment
Read 10 tweets
THREAD: Bring it down safely! ↘️💊

1/6 6⃣tweets about our new TI Therapeutics Letter 134: Finding the lowest effective dose for non-opioid #analgesics

👉🏾 Full Letter: ti.ubc.ca/letter134

#MedEd #medsafety #prescribing #BetterPrescribing Image
2/6 Consistent evidence that minority of pts get clinically meaningful pain relief from any dose of:
✅#Cyclobenzaprine (at best 1/4)
✅#Duloxetine (at best 1/6)
✅#Gabapentin / #Pregabalin (at best 1/6)

👉🏾ti.ubc.ca/letter134

#MedEd #ptsafety #BetterPrescribing #prescribing Image
3/6 Gabapentin, pregabalin, duloxetine:

A 2021 Canadian systematic review found NNT (numbers needed to treat) of 6-7 for "clinically meaningful benefit" (defined as ≥30% reduction in pain or pain & function)

👉🏾ti.ubc.ca/letter134

#MedEd #BetterPrescribing #deprescribing Image
Read 7 tweets
In the midst of all the grief + chaos of 2020, it's hard to remember there were good things

For me, an incredible group of young scholars doing highly relevant science was the #Bestof2020. Here are my favorite 2020 paper by each of several young scholars with whom I get to work
To see where some of these folks were last year see this thread

let's start this #BestOfResp2020 with @UM_IHPI K-awardees

.@msjoding changed the way I look at pulse oximetry in @nejm, rethinking my bedside care

This paper has rightly gotten a lot of attention

Read 37 tweets
1/ #Cannsolve summit with Dr. Ian Mitchell, talking on “a tale of two drugs” aka #THC & #gabapentin
2/ #Gabapentin was made by Park Davis who also made #ketamine and #cocaine
3/ #NIDA only studies drug abuse. In the US #cannabis must come from NIDA. Therefore, we can see challenges in researching the #benefits of #cannabis in US
Read 11 tweets

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