Discover and read the best of Twitter Threads about #gene

Most recents (23)

Just a friendly reminder @moderna_tx told the @SECGov that the @US_FDA defines #mRNA as gene therapy. And called it an unprecedented new category of #medicines tho they really want that #vaccine classification anyways for liability protections & fear the public wouldn’t take it.
They know the #COVID19 #vaccine isn’t a vaccine but human #gene #therapy.
The @US_FDA #fda reaffirmed their definition of modified viral #nucleic acid that alters #CELL Jan 30th 2020 #COVID ImageImageImageImage
Read 16 tweets
1/ Knowing the frequency for alleles of genomic variants in populations around the world helps us understand phenotypes and disease 🌎🌍🌏

We’re here to take you through the data in @ensembl step-by-step. A thread…🧵

#genomics #bioinformatics #tweetorial #Ensembltraining🧬
2/ The way you approach this problem will depend on if you are starting with a #gene of interest or if you already have the ID (e.g rs699) of a variant for which you want to find the observed allele frequencies.
3/ If you are starting with a gene, search for the gene name or ID from the #Ensembl homepage and navigate to the Gene tab.
Read 15 tweets
Want to learn about a gene function, but there’s no functional data in your species of interest? Or maybe looking for a homologue of your fav gene in a model organism to carry out functional work? Look no further! This #tweetorial will show you how to find orthologues in @ensembl
2/14
Let’s start on the Ensembl homepage and search for our #gene of interest SCP2 by typing its name into the search box. Then go to the gene tab by clicking on the gene name in the search results.

#Ensembltraining #genomics #bioinformatics #EnsemblCompara
3/14
You can learn more about the #gene function by exploring gene ontology terms and associated phenotypes. Let’s click on Phenotypes in the side menu. This view shows phenotypes associated with our gene of interest and variants in this gene.
Read 14 tweets
Una terapia genica per aerosol contro la fibrosi cistica? E se fosse la svolta? Vi commento la notizia. Thread spero piacevole ed interessante. 1/n 🧵
Partiamo dalle basi. Il gene #CFTR codifica per una proteina coinvolta nella regolazione degli scambi di ioni tra l’interno e l’esterno della cellula.
2/n
Quando CFTR è colpito da mutazioni, la proteina perde la sua funzione e non riesce a regolare il flusso di elementi fondamentali come il cloro, componente del sudore. 3/n
Read 16 tweets
In the endothelium,selective impairment of insulin-mediated NO production may contribute to the development of #hypertension, endothelial dysfunction, atherogenesis, insulin resistance. NO induces vasodilation and inhibits platelet aggregation, vascular smooth muscle cell growth
Angiotensin #Ang2 inhibits insulin-mediated PI3K pathway activation, thereby impairing endothelial NO production and Glut-4 translocation in insulin-sensitive tissues, which results in vascular and systemic insulin resistance, respectively.
On the other hand, Ang II enhances insulin-mediated activation of the mitogen-activated protein kinase (#MAPK) pathway, which leads to vasoconstriction and pathologic vascular cellular growth.
Read 14 tweets
Le #cellule #Car-T “peptide-centriche” contro i #tumori solidi: in questo caso ha come #target i #frammenti proteici nelle cellule di #neuroblastoma. Studio di #Nature riassunto in questo thread un po' lungo ma spero interessante. 1/13
Le basi/1. Le terapie CAR-T si basano sull’ingegnerizzazione delle #cellule T (o #linfociti T) del sistema #immunitario del #paziente, che vengono “potenziate” per combattere il #tumore. 2/13
Le basi/2. Per farlo gli scienziati usano un #vettore #virale inattivato contenente un #gene in grado di far esprimere sulla superficie delle cellule T un #recettore chimerico (il recettore dell’antigene chimerico, #CAR, a cui la terapia deve il suo nome). 3/13
Read 13 tweets
"The promise & peril of the Bio Revolution"

"...the world cheered [] that 3 #gene-based COVID19 #vaccines – 1 developed by German #biotech co. BioNTech in collab. w/ Pfizer, another by [] biotech firm Moderna, & a 3rd by [] AstraZeneca – had proved effective in clinical trials."
"But in October, researchers revealed that off-target effects of the #CRISPR-Cas9 #gene-editing tool used to repair a blindness-causing gene in the early stages of human #embryo development often eliminated an entire #chromosome or a large part of it."

#BioengineeringEconomy
"Our deepening knowledge of #biology#genes, #microbiomes, & neural signals – is making it increasingly possible to "engineer life."... #gene drives applied to infectious-disease vectors [] could save many lives, but we may not be able to control them."

#4IR #Biotech
Read 9 tweets
#COVID19 as catalyst for #4IR #biotech experimentation. The fusion of man & machine sought by the depraved. The foray of #gene editing into public realm. You are the subject.

Jan 24, 2019: "Imperial scientists present #vaccine #revolution to world leaders at #WEF in Davos"
January 2021, TIME, double issue. "The #Vaccine #Revolution" has arrived.

TIME - owned by Marc Benioff, CEO/founder of #Salesforce. World Economic Forum Board of Trustees. Inaugural Chair, Forum Centre for the Fourth Industrial Revolution, San Francisco.

#WEF #4IR #Biotech
#4IR gene-edited, flu-resistant chickens. Working w/ Roslin Inst. Barclay (Imperial) is using #CRISPR technology - to alter the #genome of a species.

April 5, 2020: One of my most thorough, informative & important threads:

Read 4 tweets
Dr Robert Malone - Q: Why do you call the #adenovirus-based (J&J) and #mRNA-based #vaccines #gene therapy-based vaccines? And why is that important? Are you just trying to scare people? Are you an #antivaxxer? linkedin.com/feed/update/ur…
why gene therapy-vaccines? both types of vaccines employ technologies that involve transfering foreign genetic material into the cells of the person receiving the vaccine, making those cells essentially become miniature vaccine antigen manufacturing factories - inside the body👉
for vaccination, the "active drug substance" is not the gene therapy vector, it is the protein that is manufactured in your cells.from an FDA/regulatory point of view, these products need to be reviewed using the regulations applied to "gene therapy" products ... 👉
Read 7 tweets
Ultimate victims of media induced fear & politically correct #posturing will be our #children. "hygiene hypothesis: "when exposure to parasites, bacteria, & #viruses is limited early in life, children face a greater chance of [] allergies, asthma, & other #autoimmune diseases..." Image
Dec 10, 2020, Nature: "'#Children are very much adapted to respond — & very well equipped to respond — to new #viruses,' [] even when they are infected w/ #SARSCoV2, children are most likely to experience #mild or #asymptomatic illness." Image
"These children’s #immune systems see the #virus & mounts this really quick & effective immune response that shuts it down, before it has a chance to replicate to the point that it comes up positive on the swab diagnostic test",

Natural #Immunity is not a conspiracy theory.
Read 12 tweets
New Concept Weapons #NCW
Directed Energy #Weapons #DEW
Force multiplier
New sword
Invisible card
People’s Liberation Army #PLA
PLA Strategic Support Force #PLASSF
new #technology testing
Disruptive #technologies
#Space Engineering University
#Chinese academic and military
#China
Force multiplier

Intelligent network and electromagnetic spectrum attack and defense weapons

“Computer chip virus” weapon

New-type psychological intervention/warfare weapons
noise intervention
holography display

Nanosatellites for intelligence collection

#China
#ChinaNCW
Read 5 tweets
#reproethicsconf2021 keynote @DorothyERoberts
It is absolutely realistic to predict that women will be prosecuted and imprisoned for having abortions. It has!!

Harmful policies, happening in the US today, we need collective movements to support reproductive rights.
2/ #reproethicsconf2021
Policies based on harmful ideologies that aim to “solve social problems”...targeting “at-risk” meaning Black, Latinx, poor communities
—-gotta listen to FULL presentation to gain understanding——
@DorothyERoberts
3/ #reproethicsconf2021
In the US, the family policing system is not intended to gain insights for solutions to help families but causes further harm bc of our punitive system @DorothyERoberts
Read 10 tweets
On #InternationalWomensDay we'd like to pause and celebrate just a small slice of the enormous contributions to science women have made here at SFI.

Read the thread below for links to some of their own favorite research papers, and a few nominated by other SFI faculty members:
First off, these papers on #FoodWebs led by our VP for #Science, Jennifer Dunne:

[@royalsociety Proceedings B]
royalsocietypublishing.org/doi/10.1098/rs…

[@PLOSBiology]
doi.org/10.1371/journa…

...and this interview she did for @QuantaMagazine:
quantamagazine.org/with-food-webs…

#Ecology #Ecologist
Next, two papers on how humans navigate and process #information co-authored by SFI External Prof @DaniSBassett (@Penn):

[@NatureHumBehav]
nature.com/articles/s4156…
+ summary:
blog.seas.upenn.edu/studying-hunte…

[@nature]
nature.com/articles/s4156…
+ summary:
penntoday.upenn.edu/news/what-do-b…
Read 21 tweets
Daily Bookmarks to GAVNet 12/15/2020 greeneracresvaluenetwork.wordpress.com/2020/12/15/dai…
CRESCAT NOVEMBER PERFORMANCE UPDATE | Crescat Capital

crescat.net/crescat-novemb…

#markets #performance
New gene family of antimicrobial proteins discovered in German cockroaches

phys.org/news/2020-12-g…

#antimicrobial #proteins #gene
Read 8 tweets
Daily Bookmarks to GAVNet 09/25/2020 greeneracresvaluenetwork.wordpress.com/2020/09/25/dai…
The lasting misery of coronavirus long-haulers

nature.com/articles/d4158…

#COVID19 #misery
Studying gene function in animal models

phys.org/news/2020-09-g…

#gene #function
Read 9 tweets
Daily Bookmarks to GAVNet 09/14/2020 greeneracresvaluenetwork.wordpress.com/2020/09/14/dai…
How CRISPR is tackling the troubling immune response that's plagued gene therapy until now

thenextweb.com/syndication/20…

#CRISPR #immune #therapy #gene #response
Less likely than being struck by lightning? Think I’ll stay indoors

unherd.com/thepost/less-l…

#AvailabilityBias #COVID19 #UnitedKingdom
Read 8 tweets
📢🎉The work of #Bat1K is featured on the cover in the latest issue of @nature: “Six reference-quality #genomes reveal evolution of #bat adaptations” 🦇🧬 #bats Our thread 👇 on the paper:nature.com/articles/s4158… 📸: Olivier Farcy(1/n) Image
📢Have you ever wondered how 🦇 manage to do what they do? #bats have extraordinary adaptations, including powered #flight, laryngeal #echolocation, #vocal #learning and an exceptional #longevity with unique #immunity and resistance to #cancer! 📸: @DanielWhitby5 (2/n) Image
A #Bat1K team led by @Sonja_Vernes @EmmaTeeling1 @hillermich @TheGeneMyers has just published the raw genetic material that codes for these unique 🦇 adaptations and #superpowers in @nature! #bats #genomics #cool! (3/n) Image
Read 32 tweets
Daily Bookmarks to GAVNet 7/01/2020-2

greeneracresvaluenetwork.wordpress.com/2020/07/01/dai…

CRISPR gene editing in human embryos wreaks chromosomal mayhem

nature.com/articles/d4158…
#human #editing #mayhem #CRISPR #gene
Distributed consent and its impact on privacy and observability in social networks

arxiv.org/abs/2006.16140

#distributed #networks #SocialNetworks
Irving Wladawsky-Berger: How Will Covid-19 Transform Urban Life?

blog.irvingwb.com/blog/2020/06/t…

#urban #coronavirus #cities #change
Read 5 tweets
سلسلة هذه التغريدات توضح بعض المصطلحات الطبية المستخدمة بشكل كبير في مجال جينوم البكتيريا
(Bacteriol genomes 🧬 )
:
#بكتيريا #علوم_طبية
#microbiology #genome #gene #InfectiousDisease #Biotechnology #biology
#ثريد #مختبرات_طبية
1- Agglutination: يعبر عن تجمع البكتيريا و الاجسام المضادة المغلفة بـ اللاتكس عند وجود مستضد/ (antigen ) معين.
2- Antimicrobial: يعبر عن العامل الذي يقتل او يمنع الكائنات الحية الدقيقة من النمو من بكتيريا، فيروسات وفطريات.
Read 26 tweets
Artemis
متصفح مصمم للجينوم
(genome)
والذي تم تطويره من قبل العلماء والباحثين في معهد
Wellcome Sanger institute
يتم من خلال هذا المتصفح قراءة وتصور سلسلة DNA 🧬 للبكتيريا. Image
سـ أذكر هنا في سلسلة هذه التغريدات عن:
١-مقدمة تعريفية عن الجينومات البكتيرية
(bacterial genome)
٢-أهمية متصفح الجينوم( genome browser )
٣- كيف يساهم هذا المتصفح Artemis في دراسة مسببات الامراض البكترية
#biology #Bioinformatics #gene #Bacteriology
تمتلك الجينومات البكتيرية مجموعة من الأحجام ويمكن أحتوائها على واحد أو أكثر من الكروموسومات ويمكن ان تكون هذه الكروموسومات دائرية أو خطية (circular or linear).وبغض النظر عن شكلها تظهر الجينومات البكتيرية ارتباطاً كبيراً بين حجم الجينوم وعدد الجينات الموجودة في الجينوم. Image
Read 11 tweets
#COVID19.

Important thread.

Q: What does #Imperial College, the World Economic Forum (#WEF), #Salesforce, #Sinovation Ventures (Chinese technology venture capital), #ABB (#automation technology), global artificial intelligence (#AI), all have in common? Image
A: #Vaccines, #EmergingMarkets, #gene editing - via the Fourth Industrial Revolution

[It is important to Important to note that on June 13, 2019 WEF officially partnered with the UN. On March 11 2020 it announced partnership w/ WHO to form "COVID Action Platform for business." ImageImageImageImage
Jan 24 2019: "Imperial scientists present #vaccine revolution to world leaders at WEF in Davos"

Academics from Imperial's Network for Vaccine Research, joined heads of G20 & other states, #CEOs of #multinationals, members of int. orgs & other scientists at the #WEF meeting. ImageImageImageImage
Read 30 tweets
1/ Thread: New study forthcoming on whether #gene-testing can help guide #antidepressant selection for #depressed patients who have failed to respond to 1 or (on average) 3-4 trials of medication. bit.ly/2LQU75I I have been skeptical: mostly, scant added value…
2/ & I found the reporting of this study annoying. On the primary endpoint, improvement in average #depression rating scores, the gene-testing failed. Patients whose MDs chose new meds w/o help of gene tests did just as well—& yet news reports suggested that tests can help…
3/ That's because the gene testing led to a choice of new meds that led to significantly more remissions (patient no longer depressed) and responses (halving of symptom burden). In general, in drug trials, response/remission shows antidepressants to better effect…
Read 7 tweets
Team searches for prokaryotic small #proteins in #HMP dataset that are traditionally hard to detect 👉 Describe more than 4000 conserved protein families, most of which are novel (90% have no known domain, and ~1/2 are not represented in reference genomes):biorxiv.org/content/early/… ImageImageImageImage
Small #proteins identified by the team are 👉 potentially involved in crosstalk w/ the host or other #microbial cells, may be subject to horizontal #gene transfer...and may be related to defense against #phage or other bacteria (among other functions!): biorxiv.org/content/biorxi… Image
Also, important previous discoveries by Ami S Bhatt and @kyrpides (both authors of the small protein paper) 👉 are featured in my recent article: “My favorite 2018 #papers that impact the study of chronic inflammatory disease”☝️Check them out: microbeminded.com/2018/12/30/myf… ImageImage
Read 3 tweets

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