Discover and read the best of Twitter Threads about #geneeditsummit
Most recents (4)
BREAKING: Any more babies out there? Big question at end of #geneeditsummit in HK
NEW==> Jiankui He registered a *second* study on PCSK9 (low heart disease risk)
Says only involves embryo (no transfer).but who knows.
H/t @erikwestin for inspiration
chictr.org.cn/showprojen.asp…
NEW==> Jiankui He registered a *second* study on PCSK9 (low heart disease risk)
Says only involves embryo (no transfer).but who knows.
H/t @erikwestin for inspiration
chictr.org.cn/showprojen.asp…
Let’s hear from @matthewherper about CRISPR babies versus Repatha. The baby approach will be more cost effective😝, but can’t undo ☹️
FYI, I think this trial listing discloses the prelim research on embryos both for CcR5 and pcsk9
Here's my take on the protein sequences encoded by the alleles reported at #geneeditsummit for #CRISPRbabies. Lulu's mutation (delta15) leads to a five amino acid deletion, but the protein largely resembles wild type. The consequence of this mutation is unknown... (1) Thread 
Nana has two different mutations (excluding possible mosaicity). The first (ins1) leads to a variant that is similar to the well-studied delta 32 variant, except it has an additional 11 amino acids that are neither in WT or delta 32... (2) Thread
Her second mutation (delta 4) produces an even shorter protein than wild-type or delta 32. It also contains nine amino acids not present in any of the other variants. The phenotypic consequence of either of these mutations (ins1 or delta4) is unknown to my knowledge. (3) Thread
holy cow Harvard Medical School dean George Daley is making the case, big time, and eloquently, FOR editing embryos, at #geneeditsummit
he is says technically we are *ready* for RESPONSIBLE clinic use.
he is says technically we are *ready* for RESPONSIBLE clinic use.
he's basically saying, stop debating ethics, start talking about the pathway forward
and the pathway looks A LOT LIKE THAT TAKEN BY DR. HE (crispr baby guy)
and the pathway looks A LOT LIKE THAT TAKEN BY DR. HE (crispr baby guy)
hes talking about possible uses ---
green light for mendelian
green for "modifying disease risk." !! i.e. CCR5
green light for mendelian
green for "modifying disease risk." !! i.e. CCR5
HISTORIC Livestream Tonight: 7:30pm ET, Nov 26
#GeneEditSummit
In vitro (in the glass) genetic manipulation of artificially inseminated human eggs and sperms.
2nd: Hong Kong -- Nov, 27-29, 2018
nationalacademies.org/gene-editing/2…
1st: Wash DC -- Dec, 1-3, 2015
nationalacademies.org/gene-editing/G…
#GeneEditSummit
In vitro (in the glass) genetic manipulation of artificially inseminated human eggs and sperms.
2nd: Hong Kong -- Nov, 27-29, 2018
nationalacademies.org/gene-editing/2…
1st: Wash DC -- Dec, 1-3, 2015
nationalacademies.org/gene-editing/G…
#GeneEditSummit Update 1 for citizen journalists covering 'medical': Definitely listen Dana Carroll's presentation (when archived). After listening, if it still seems too technical, then also read this book (learn their 'terms of art'!):
amazon.com/Crack-Creation…
amazon.com/Crack-Creation…
#GeneEditSummit Update 2 for citizen journalists: transcript of Dana Carroll's presentation -- "genes genomes genetic variation" -- here: diyhpl.us/wiki/transcrip…
HT to @kanzure for the transcript.
HT to @kanzure for the transcript.
