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Please notice: we revealed that SARS-CoV-2 ORF3b, one of the most different genes compared to SARS-CoV, strongly hampers human type I IFN activation. Its inhibitory activity is stronger than the SARS-CoV ortholog and influenza A virus NS1. #COVID19 1/7
biorxiv.org/content/10.110…
biorxiv.org/content/10.110…
Our findings may explain the poor IFN responses in #COVID19 patients and SARS-CoV-2-infected cells compared to SARS-CoV- and influenza A virus-infected cells, recently reported by @DBM003 @virusninja and so on, are attributed to the remarkable ability of SARS-CoV-2 ORF3b. 2/7
Additionally, we revealed that the ORF3b genes of SARS-CoV-2-related viruses in bats and pangolins are very similar to that of SARS-CoV-2 and possess the activity to inhibit IFN activation. 3/7
