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Proud to share our latest publication which shows how to synthesize a library of #glycopeptides at microgram scale in a parallel and cost effective manner published in @CellChemBiol
cell.com/cell-chemical-…
Collaboration between @theNCFG @NPohl_Group & @BoyceLab
#glycotime
cell.com/cell-chemical-…
Collaboration between @theNCFG @NPohl_Group & @BoyceLab
#glycotime
The method is based on SPOT synthesis technique (classically used to produce non-glycosylated peptides), which we modified to help with special conditions required for glycoamino acids (which are more fragile). We also developed a biopsy sampling technique to monitor reactions.
Synthesis can be done without need for specialized equipment, in a chemical fume-hood with filter paper/cellulose (solid support), a glass food lock-lock type container and chemical reagents used in traditional FMOC peptide chemistry and other common lab equipment e.g. pipettes.
