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Eosinophilic cytoplasmic bodies in melanocytes.

Perhaps one of the most overlooked findings in #dermpath -according to me-. I will show all the cases Iโ€™ve found since ~April 2020 (around 20 cases) and say a few words about #Gottliebbodies ๐Ÿ‘‡๐Ÿผ

#dermtwitter #PathTwitter Image
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๐Ÿ”ดGottlieb bodies

I donโ€™t spend much more time looking for them, I only search when I see sebocyte-like melanocytes (not that rare)

๐Ÿ“ eosinophilic cytoplasmic body within an -usually-multinucleated vacuolated melanocyte
๐Ÿ“ small incipient ones have basophilic appearance ImageImageImageImage
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๐Ÿ“ larger fully developed ones have concentric lamination with eosinophilic staining
๐Ÿ“ thought to represent degenerative changes in melanosomes, although this study doesnโ€™t support such theory ๐Ÿ‘‰๐Ÿผ pubmed.ncbi.nlm.nih.gov/21819442/ ImageImageImageImage
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