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🚨Is sodium bicarbonate useful to prevent Rhabdomyolysis induced AKI ❓❓🚨
We get asked this all the time! But in order to understand it, let's start with a simple question
What is the mechanism of AKI in rhabdomyolysis ❓❓
🚨Is sodium bicarbonate useful to prevent Rhabdomyolysis induced AKI ❓❓🚨
We get asked this all the time! But in order to understand it, let's start with a simple question
What is the mechanism of AKI in rhabdomyolysis ❓❓
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1⃣What happens in rhabdo?
⚡️Muscle necrosis → release of intracellular components (enzymes-CK, electrolytes & myoglobin)
⚡️Fluid sequestration within damaged muscle → volume depletion →🚨 RAAS➕SNS
⚡️Oxidative injury →⬆️ in vascular mediators → ⬇️renal blood flow
1⃣What happens in rhabdo?
⚡️Muscle necrosis → release of intracellular components (enzymes-CK, electrolytes & myoglobin)
⚡️Fluid sequestration within damaged muscle → volume depletion →🚨 RAAS➕SNS
⚡️Oxidative injury →⬆️ in vascular mediators → ⬇️renal blood flow
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We might see ⬆️Creatine Kinase (CK) levels somewhat frequently...
BUT...
Is there a CK level that predicts AKI❓
⚡️There is no defined threshold value of CK
⚡️CK levels < 15,000 to 20,000 U/ L on admission usually have a low risk of AKI
pubmed.ncbi.nlm.nih.gov/16490621/
We might see ⬆️Creatine Kinase (CK) levels somewhat frequently...
BUT...
Is there a CK level that predicts AKI❓
⚡️There is no defined threshold value of CK
⚡️CK levels < 15,000 to 20,000 U/ L on admission usually have a low risk of AKI
pubmed.ncbi.nlm.nih.gov/16490621/
