Discover and read the best of Twitter Threads about #gs441524
Most recents (5)
I have wondered why ph2/3 #VV116 trials exclude participants with eye disease (super specific imo)
From study protocol: Conjunctiva and cornea changes were noted in dogs treated at 250 mpk
A VV116-specific effect or also applicable to #GS441524 prodrugs @GileadSciences?
From study protocol: Conjunctiva and cornea changes were noted in dogs treated at 250 mpk
A VV116-specific effect or also applicable to #GS441524 prodrugs @GileadSciences?
I am reminded of the FDA-approved ocular drugs that are ester prodrugs. Added lipophilicity + esterase expression in cornea might explain preclinical ocular tox with VV116 in dogs.
When did @GileadSciences decide that #GS441524 hypothesis was valid? Clues in patent history🔍
While Gilead bashed GS-441524 in 2020, they quietly worked on oral prodrugs
Could we have had an oral COVID pill in late '20/early '21? 💊
I think YES 🧵1/16
worldwide.espacenet.com/patent/search?…
While Gilead bashed GS-441524 in 2020, they quietly worked on oral prodrugs
Could we have had an oral COVID pill in late '20/early '21? 💊
I think YES 🧵1/16
worldwide.espacenet.com/patent/search?…
Patent on oral GS-441524 prodrugs has 1st priority filing on AUGUST 27, 2020. So they did not think the '524 hypothesis was worthless in 2020. 2/16
statnews.com/2020/05/14/gil…
statnews.com/2020/05/14/gil…
Context: @Muller_Lab & I published an Opinion in @statnews urging Gilead to pursue dev of #GS441524 in May 2020 (above)
On June 24, 2020, we first met w Gilead science leadership, who indicated they were not interested. 3/16
medium.com/@victoriacyani…
On June 24, 2020, we first met w Gilead science leadership, who indicated they were not interested. 3/16
medium.com/@victoriacyani…
BIG NEWS: deuterated #GS441524 tri-iBu ester (#VV116) is in clinical trials in Uzbekistan for #COVID19. Trials in China 🔜. Developed by the one and only *Wuhan Institute of Virology*. Deuterium was added to bypass @GileadSciences 💊 1/4
@ncats_nih_gov
shine.cn/news/nation/21…
@ncats_nih_gov
shine.cn/news/nation/21…
Official article published in @cell_res in September 2021 by the folk at Wuhan Institute of Virology. Original @biorxivpreprint was published in November 2020. 2/4
nature.com/articles/s4142…
nature.com/articles/s4142…
Chinese patent by the WIV first filed in Sept 2020. WO patent filed in April 2021. Gilead's 2009 patent on 524 and the 2016 patent on #remdesivir do not include any of the compounds described in the WIV patent. Does Gilead actually own any of these WIV compounds?? 3/4
First-in-Woman Safety, Tolerability, and Pharmacokinetics of Orally Administered #GS441524: A Broad-Spectrum Antiviral Treatment for #COVID19. A 🧵1/7 osf.io/am5s8/
Part 1 of the study: 750 mg GS-441524 was orally administered as a solution QD for 7 days. D1-5 were performed in the fasted state. D6-7 in the fed state. There was a slight food effect that seemed to hamper drug absorption. Cmax ~2.4-3 uM. AUC ~26-33 uM. 2/7
No AEs or lab abnormalities were observed in Part 1 of the study. Blood chemistry was normal. 3/7
Fun fact: #remdesivir is almost certainly not the species that reaches #COVID19 patients' lungs! Its nucleoside #GS441524 is. Wrote this piece for @statnews explaining this! @GileadSciences consider aerosolizing GS-441524 prophylaxis. Pls read and RT! 1/x
bit.ly/3dIc0Au
bit.ly/3dIc0Au
I've been reading a lot of general audience/science articles on #remdesivir. Many of these articles seem to confuse nucleoSIDES with nucleoTIDES. Here's the difference, feat. important figures. 2/x
