Discover and read the best of Twitter Threads about #gupath

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So many great tutorials lately, I’ll contribute this review on some prostate cancer basics.
Prostate cancer 101
Random section from a prostatectomy for cancer.
@slusagar @TheKarenPinto @Williamson_SR @ariella8 @MELanocyteMD @TedFarMD @mhassanaimc
2. Slightly higher power, ill address each of the circled areas.
3. Orange box: Atrophy. Make a mental note of the lobulated architecture (red circles), a benign feature.
Read 11 tweets
History: Female, 50-ish, presented with hematuria.

Cystoscopy: Congested mucosa with bleeding ulcers

Biopsy from urinary bladder lesion

#pathology #GUPath
What should I do?
I should call the surgeon

“Did the patient have urinary bladder cancer before?”

Patient had cervix cancer, a year back
Read 17 tweets
Painless hemiscrotal mass in a child, complex hydrocele on ultrasound.

Testis mass + smear... Fight!

#pedipath #gupath #cytopath
Rhabdomyosarcoma is indeed the top-level diagnosis... but more importantly, what type??

Note: several H&E patterns here that correspond nicely to the patterns on cytology.

#pedipath #gupath #pathology
Note the multiple patterns here - and see how they relate to myogenin staining.
This is an uncommon example of mixed-histology rhabdomyosarcoma.

Classic Embryonal - variable myogenin
Dense Emb/Solid Alveolar - strong, diffuse myogenin
Sclerosing - Weak/absent myogenin

Read 5 tweets
#GUpath puzzler time!
(for those of you familiar with this case, please keep 🤫!)

middle aged M found to have bilateral breast enlargement. Work-up revealed elevated serum PSA. MRI-guided prostate biopsy done of abnormal area seen on imaging.

my DDx:
▶️Gleason 5+5 prostatic adenocarcinoma (for all new bx cases, I always do confirmatory prostate #IHCpath)
▶️plasmacytoid urothelial carcinoma
▶️signet ring GI tract adenocarcinoma
▶️metastatic lobular carcinoma
not shown but negative were:
NKX3.1/PSAP, CK20, uroplakin2
Read 9 tweets

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