Discover and read the best of Twitter Threads about #gut

Most recents (22)

Does #gut #microbiota interact with #microglia in the #aging #brain? Are microglia metabolically affected (#mitochondria)? Does #diet take part? any #translational data?
Our paper made it last week in @NatureNeuro
so it's about time for a 🧵!
nature.com/articles/s4159… Image
1. Microglia from aged and young-adult #male & #female mice, under SPF or #germ_free conditions were profiled by bulk #RNAseq. We identified a gene-set, which depended on the housing condition regardless of #age & regulate central processes in microglia. "Microglial GF signature" Image
2. Utilizing #WGCNA, we found major differences between microglia of SPF and GF mice in the aged groups. But do we see any functional difference on a cellular level? Image
Read 13 tweets
1/6
Wir wollen es Mal in #Euro hören und sehen, was #KINDER in #Deutschland wert sind!
@OlafScholz
@HendrikWuest
@Karl_Lauterbach
Also:
Sie sind keine #Luftfilter wert 100€
Sie sind keine #Maske wert 20€ p.M
Sie sind keine #gut ausgestatte #Schulen wert. 1000€ p.J.
2/6
Sie sind keine #PCRtests Wert.70€
Sie sind es nicht #Wert durch die #Unfallkasse vor den #Folgen einer #Coronainfektion geschützt zu sein, da ihnen das #Recht auf #Beweismittel #PCRtest genommen wird.
Sie sind es nicht #Wert, dass es für #Kinder Studien zu #LongCovid gibt.
3/6
Das heißt, #Familien sind die #verlierer der #Pandemie!
#Kinder und #Familien werden von #Politikern skrupellos durchseuchen, ohne auch nur über die #Folgen einer #Coronainfektion umfassend informiert worden zu sein.
Die #Familien werden dieses #Leid der Kinder tragen müssen
Read 6 tweets
While we're beginning to understand more and more about the #microbiome, research on the #mycobiome (fungi 🍄) is in its infancy. Here is my summary of 🔑 points from @aeprobio's seminar on the latest research on fungi and the gut!

#GITwitter

Bacteria in the #gut outnumber fungi as a class, but at the individual species level can occur in the same numbers.
Most #gut fungi belong to Ascomycota or Basidiomycota
Read 43 tweets
Thank you so much to @DrPraegers for having me to discuss the effects of plant-based diets on the #gut #microbiome! Here are my slides for all to see! 😃

🍅🥑🧅🍑🥦🍒🫑🍊🌶️🍎🍆🍊🫒🍓🥒🍉🥗🥝🦠

#medicine #medtwitter #diet #nutrition #GITwitter #GI #guthealth #health
Just as we do things for heart health and brain health, our #microbiome is an organ of its own (the size of a 🥭), so we need to take care of it!
Read 30 tweets
Buckle up! This 🧵 is a deep dive into the #physiology of defecation, the mechanics of pooping! 🧰 🚽 💩

nature.com/articles/s4157…

#medicine #MedEd #science #GITwitter #GI #gut #motility #constipation #IBS
Defecation requires
1. intact #GI tract
2. coordination of many systems: neural (enteric nervous system, modulated by the peripheral somatic, autonomic and the CNS); muscular (smooth and striated); hormonal (endocrine and paracrine); and cognitive (behavioural and psychosocial)
#Constipation is the3⃣rd most common #GI symptom

💰 Annual cost of fecal incontinence and constipation: $1,594 - $7,522
Read 31 tweets
Here are the new @BritSocGastro guidelines for #IBS in @Gut_BMJ! I'll summarize in 🧵 ⬇️⬇️⬇️!

😖💩🦠🧠🥦🍞💊

#GITwitter #GI #gut #braingut #motility #DGBI #FGID #microbiome #probiotics #MedTwitter #MedEd

gut.bmj.com/content/early/…
🧑‍⚕️-😷
Doctor-patient communication
🧑‍⚕️A strong 🧑‍⚕️-😷 relationship is fundamental to the management of #IBS
😷Patients want their 🧑‍⚕️ to ⬆️empathy, support and information about the nature of IBS, diagnosis, and treatment options
DIAGNOSIS
🩸New pt: CBC, CRP or ESR, celiac serology and, if <45 w diarrhea, fecal calprotectin
➕Make POSITIVE diagnosis based on @RomeFoundation criteria
➡️Refer to #GI when: diagnostic doubt, pt w symptoms that are severe or refractory to 1stline tx,or when pt wants specialist
Read 16 tweets
Foods in our #diet can alter the pro-inflammatory vs anti-inflammatory milieu of the intestinal #microbiome.

See 🧵 below for the findings!

🥬🍑🍅🍠🥚🍎🧀🍆🫒🫓🍇🥦🥑🥥🥯🌶️🧄🥖

#GITwitter #GI #gut #nutrition

gut.bmj.com/content/early/…
🥖 🥜 🐠 🌰
Breads, legumes, fish and nuts⬇️several pro-inflammatory pathways:
🫓⬇️pathogenic growth factors & endotoxins
🫓⬇️ pathogenic E. coli, Bacteroides fragilis, parabacerioides
🫓⬆️ammonia detoxification pathway
🌰🐟 🍑🥦
Nuts, oily fish, fruit, vegetables & cereals ⬆️short-chain fatty acid producers
🫑⬆️Faecalibacterium prausnitzii, roseburia hominis, and more

Bacteria ferment fiber and pectins to acetate and butyrate.

SCFAs have anti-inflammatory effects on the mucosa!
Read 20 tweets
A little late but better late than never! ⌚️ Here's a recap of @AmCollegeGastro Virtual Grand Rounds by @ScottGabbardMD on...... FUNCTIONAL DYSPEPSIA!
🤢🤢🤢

This is a VERY common entity that is underdiagnosed! #MedTwitter take notice!

#GITwitter #GI #gut
DYSPEPSIA = epigastric #pain. (can be associated with any other upper #GI symptom such as epigastric fullness, nausea, vomiting, or heartburn).

Dyspepsia is COMMON, and most cases are FUNCTIONAL (i.e., caused by brain-gut axis dysfunction)!
Like all disorders of gut-brain interactions FD pathophysiology is❌completely understood, but is thought to be complex+multifactorial. Components include
🤢disrupted duodenal barrier
🤢altered duodenal #microbiome
🤢dysmotility
🤢visceral hypersensitivity
🤢psychosocial stress
Read 22 tweets
Let's talk about something common, hard to treat, and often misunderstood: CHRONIC BLOATING AND DISTENSION!

A 🧵 summarizing from the excellent @AGA_CGH article cghjournal.org/article/S1542-…

#GI #GITwitter #motility #IBS #DGBI #FGID #microbiome #health #MedEd
🟢Bloating: subjective sensation of gassiness, trapped💨, or a feeling of pressure or being distended w/o obvious visible distension.

🟢Distension: objective physical manifestation of an⬆️in abdominal girth. Patients commonly say they look like 🎈 or 🤰
Bloating and distension are COMMON

🔴16-31% in the general population

🔴Women > men

🔴66-99% in #IBS

🔴IBS-C > IBS-D

🟢Bloating and distension are distressing to patients and ⬇️quality of life
Read 13 tweets
Latest paper is up! We fed mice high protein diets for 24 weeks and measured the #microbiome 🦠, #kidney function and #gut leakiness. Here's what we found: onlinelibrary.wiley.com/doi/abs/10.100… @sihmin_tan @MelindaCoughlan @MonashDiabetes
1) high protein diets alter the microbiome...but what's interesting is when we looked at the predicted metagenomes (using picrust2) we saw⬇️BCAA synthesis and⬆️urea cycle pathway.
2) the high protein diet caused inflammation and intestinal permeability:
⬆️ plasma endotoxin
⬆️ plasma MCP1
⬆️ TNFα expression in jejunum and ileum
⬇️ occludin expression in jejunum
Read 5 tweets
🚨New @AmCollegeGastro guidelines for the treatment of irritable bowel syndrome! I will summarize in this🧵 ⬇️⬇️⬇️

journals.lww.com/ajg/Abstract/9…

Authors: #BrianLacy, @MarkPimentelMD, @dbrennerGIMD, @umfoodoc, @drlauriekeefer, @MLongMD, @BMoshiree

#GITwitter #GI #IBS #gut #MedEd
🔘In pts w diarrhea, rule out #celiac disease🍞
🔘In pts w diarrhea + no🚨features, check fecal calprotectin/fecal leukocytes AND CRP to rule out #IBD
🔘❌routine 💩testing for enteric pathogens in #IBS
🔘❌colonoscopy in IBS if <45 and no🚨s
🔘Make POSITIVE IBS dx (Rome), ❌DOE
🔘Identify #IBS subtype to target therapy
🔘❌testing for food allergies/sensitivities
🔘Test anorectal physiology in pts w IBS + symptoms suggestive of pelvic floor disorder +/or refractory #constipatoin
🔘Limited trial of low-#FODMAP #diet
🔘✅soluble fiber,❌insoluble fiber
Read 7 tweets
Recapping @AmCollegeGastro's #VirtualGrandRounds on #IBS! Let's begin!
🟣IBS can be diagnosed with the Rome criteria
🟣Making a positive diagnosis is very helpful to patients, many of whom have gone years without a name for their symptoms
#IBS is heterogeneous, and so are its pathogenesis and pathophysiology.
🟣Identifying underlying factors in patients can help target treatment!

@AmCollegeGastro
Important principles when diagnosing and treating #IBS.

@AmCollegeGastro
Read 34 tweets
After 6 months of #lockdown and #lab shutdown I spent a full day 9 am-8 pm in lab doing experiments! New #grad students in #lifesciences: There is always light 💡 and #fluorescent images at the end of the tunnel! Filing a #patent on my #invention from #phd work soon @OrganOnAChip
This is an Organ on a Chip platform that enables mimicking #tissues and #organs in a high throughput manner! The main focus will be towards developing #mucosal organs with tissue resident #immune cells and lining #epithelial cells for #testing #COVID19 treatments #covidvaccines
I recently gave a talk at #oooc2020 organized by @GVNlab at @Columbia. In the talk I demonstrated the #ease of fabrication, #functionality, and #modularity of this platform.
We’re open to #collaborate with interested #researchers! Interested to learn more:
Read 11 tweets
Daily Bookmarks to GAVNet 6/06/2020-2

greeneracresvaluenetwork.wordpress.com/2020/06/06/dai…

Coronavirus May Be a Vascular Disease, Which Explains Everything | Elemental

elemental.medium.com/coronavirus-ma…

#vessels #blood #coronavirus #disease
Out-of-Sync ‘Loners’ May Secretly Protect Orderly Swarms

abstractions.nautil.us/article/561/ou…

#individual #swarm #nautilus
Opinion | The ‘Liberal World Order’ Was Built With Blood - The New York Times

nytimes.com/2020/05/29/opi…

#liberal #blood #order #world
Read 12 tweets
Daily Bookmarks to GAVNet 5/19/2020-2

Podcast: Galileo and the science deniers, and physicists probe the mysterious pion

nature.com/articles/d4158…
#Science #Galileo
Meet the ‘psychobiome’: the gut bacteria that may alter how you think, feel, and act

sciencemag.org/news/2020/05/m…
#action #gut #bacteria #feel #think
How do children spread the coronavirus? The science still isn’t clear

nature.com/articles/d4158…
#Children #spread #coronavirus
Read 8 tweets
🤓Here are our lecture presentations for #DDW2020
1/1 #Gut #microbiota and role in clinical events & #treatment response in #alcoholic #hepatitis. LEfSE, Conet and NetworkX analysis.
@AASLDtweets @DDWMeeting @AmerGastroAssn #medtwitter #MedEd #AcademicTwitter Image
2/3 Introducing 'Anticipant TIPS' in #cirrhosis and #portal hypertension Image
3/3 Role of GM CSF therapy in advanced cirrhosis awaiting #Liver #transplantation Image
Read 3 tweets
Virophages are small #viruses w/ double-stranded DNA genomes that replicate along with giant viruses + co-infect eukaryotic cells 👉@DaviPaez @kyrpides + team just published this study which increased the number of known virophage genomes by 10-fold!: microbiomejournal.biomedcentral.com/articles/10.11… ImageImage
2/ It’s the first study to identify HQ virophage genomes in diverse habitats including #plant-associated, thermal #springs, deep-subsurface and #cow rumen...
3/ AND...it’s also the first study ever to identify virophages in human #gut samples! 👉 4/5 human-associated HQ virophage genomes were identified in #fecal samples recovered from individuals with a rural lifestyle, the other was found in a patient w/ ulcerative #colitis Image
Read 3 tweets
This pilot study found that certain strains of #bacteria in Parmesan cheese (which are derived from cattle gut, milk and the local #environment) can colonize + persist in the guts of people who consume the cheese on a daily basis: nature.com/articles/s4146… ImageImage
2/ The findings suggest that globalization must be impacting gut #microbiome composition in a growing # of people 👉 Think how an average USA supermarket imports cheese + other #foods from around the globe, meaning people are often consuming an “international” mix of #organisms
3/ I wonder if, in some people, the #gut is not prepared for influxes of so many different global organisms, and/or lacks #immunity against certain strains 👉 If yes, that cld partly explain why people who “eat locally” (their #food comes from the same area) sometimes feel better
Read 3 tweets
Incredible new study 👉 Demonstrates that #gut-innervating nociceptor #neurons modulate several layers of GI physiology including regulation of #Payers Patch M cells + small intestine microbial communities + defense against enteric pathogen Salmonella: sciencedirect.com/science/articl… ImageImageImage
2/ Overall the study expands the role of the #nervous system in host defense and suggests that “manipulation of #neurons and their mediators could be a target for therapies to treat inflammatory and #infectious diseases”
3/ For more info on the study check out this press release which describes the findings in more simple terms: news.harvard.edu/gazette/story/…
Read 3 tweets
Just published: Team uses mNGS + culture-based techniques + negative controls 👉 Identify fungi + bacteria in complex communities in the first pass meconium (stool) of infants☝️Indicates that the neonatal gut microbiome starts to form in the womb: biorxiv.org/content/10.110…
2/2 The organisms they identified colonizing the fetal #intestine prior to birth 👉 were identified in the meconium of both term-born and #preterm newborns☝️And machine learning suggested that #fungal gut communities develop in complexity w/ advancing gestational age at birth.
3/3 Quote from paper 👉 “The demonstration of live #microorganisms in the #newborn gut represents a monumental shift from the sterile #womb hypothesis that dominated perinatal biology for the last century...”
Read 7 tweets
Incredibly important hypothesis piece published today 👉 “Proposed here is a theory that #microorganisms from within the #brain and elsewhere in the body contribute to the long-term #neurological deterioration characteristic of traumatic brain injury”: sciencedirect.com/science/articl…
From paper 👉 1. “First, since the normal human #brain is not sterile, but is host to a variety of microorganisms, blows to the #skull may dislodge them from their accustomed local environments, in which they have been living in quiet equilibrium with neighboring #brain cells”
2. “2nd, upon impact commensal #microbes already resident on surfaces of the nose, mouth + eyes, and potentially harmful organisms from the environment, may gain access to the #brain through the distal ends of the olfactory + optic #nerves or even a disrupted blood-brain barrier”
Read 6 tweets
Researchers studying neuroinflammation + patients who’s chronic conditions started w/ a viral #infection need to read this 👉 It clarifies how viruses able to persist in the #brain (including strains of influenza) can drive a range of debilitating symptoms:the-scientist.com/features/can-t…
Some highlights regarding viral persistence 👉 “Here, you’re talking about decades. The #virus goes in and then maybe decades later it can cause some potentially serious neurodegeneration -Anthony van den Pol, Yale University Image
And this 👉 “So these were two different [flu #viruses], two different mechanisms, but the same effect in a sense...They were inducing #inflammation and death in the parts of the brain that we see degenerate in #Parkinson’s disease.” - Richard Smeyne (Thomas Jefferson U) Image
Read 4 tweets

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