Discover and read the best of Twitter Threads about #haploinsufficiency
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1/ Today in @ScienceMagazine, @aspaan1 & colleagues show that human #OTULIN #haploinsufficiency impairs non-leukocytic cell-intrinsic immunity to the #staphylococcal alpha-toxin (science.org/doi/10.1126/sc…).
2/ They discovered OTULIN haploinsufficiency via a genome-wide approach in a cohort of patients with unexplained, life-threatening staphylococcal disease – the findings are relevant in vivo. 
3/ The clinical hallmark of OTULIN haploinsufficiency is necrosis of the skin and/or lungs, typically triggered by infections with #Staphylococcus aureus.
