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Let’s start with # 1: treating metastatic disease.

Metastasis is when tumor cells grow in a place different from where the primary tumor was found.

Common sites of metastasis for breast cancer (ductal) are liver, bones, lungs, and brain.
People don’t usually die from breast cancer bc they have primary disease, they die because the metastasis has taken over other organs in their body.

For some, chemotherapy or targeted therapies for ER+ and Her2+ can keep the metastatic disease at bay for months or even years.
From a biological standpoint, metastasis is a bit of conundrum.

A cell(s?) leave the primary, enter the blood steam, leave the blood stream somewhere else, and set up shop.

This process has many normal checkpoints that should stop it from happening.

📷: semanticscholar.org/paper/The-path…
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