Discover and read the best of Twitter Threads about #hematopathology

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#HematologyTweetstory #6: the ‘pawn ball megakaryocyte’. We’ll revisit Dr. Frankenstein from Tweetstory #1, discover the origin of Santa Claus, and travel from Boston to Las Vegas – a flight the clever guys from the MIT Blackjack Team used to make every Friday. #hematopathology/1
‘Pawn ball’ megakaryocytes have 3 distinct nuclear lobes; this is abnormal. The first reference I’ve found that uses this term is a 1984 @BloodJournal paper by David Rosenthal & William C. Moloney (1907-1991). Dr Rosenthal @DanaFarber led @Harvard Health Services until 2011/2
Moloney, who became the champion of the 'pawn ball meg.' concept, came from @TuftsMedicalCtr & the old Boston City Hospital to become hematology chief at Peter Bent Brigham Hospital (now @BrighamWomens) in 1966. He continued to work until he turned 90 in 1997. @BrighamHeme /3
Read 22 tweets
Time for #hematology-#hematopathology-#history #tweetorial 4: the striking Pelger-Huët anomaly! These curious cells, sometimes mistaken for neutrophil bands, can be inherited; if acquired, they are often a sign of #MDS. I took this photomicrograph of a characteristic example./1 Image
There have been a few histories of the Pelger-Huët anomaly published over the years; a particularly nice one was done by my friend @mrinal90151372 @MayoClinic and colleagues in the American Journal of Hematology 2009). The below Tweets include original research. #PelgerHuet /2 Image
Karel Pelger (1885-1931) – often erroneously written “Karl” in reviews - was born in the village of Nijeveen in rural Drenthe in the Netherlands. Though a country boy who disliked cities, he lived in Amsterdam because of his enthusiasm for science & better access to facilities./3 Image
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