Discover and read the best of Twitter Threads about #hemepathmda
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Just another ordinary day at #hemepathMDA … 🤯
60-70 y/o woman
To all brave #hemepath aficionados how would you classify this case?
Poll and individual high quality images below. Pls comment if you’re feeling particularly brave today, let’s talk new #WHO 😎
60-70 y/o woman
To all brave #hemepath aficionados how would you classify this case?
Poll and individual high quality images below. Pls comment if you’re feeling particularly brave today, let’s talk new #WHO 😎
What’s your dx?
Better quality images
Happy to share our latest paper w/ @SibaElHussein as lead author, out today in @BMTjournal ⚡️Acquired WT1 mutations contribute to relapse of NPM1mut AML following allogeneic hematopoietic stem cell transplant rdcu.be/cEuxv #hemepath #leukemia #hemepathMDA
WT1 mutations are present in ~7% of de novo AML, are typically Lof mutation involving exons 7-9 of the gene. They frequently (~15%) co-occur w/ NPM1mut & have detrimental impact in this setting, shown by @AkEisfeld and colleagues in bit.ly/3eWQtXw @LeukemiaJnl
We studies a cohort of de novo NPM1-mut AML. 7% had concurrent WT1 mutations at baseline. 22% (15/67) relapsed; 4 (27%) with newly acquired Lof WT1-mut. Illustrated by @furudateken
(1/5) AML with NPM1 mutation ⬇️
Characteristically prominent nuclear invaginations imparting a “cup-like” or “fish-mouth” morphology, with very strong MPO positivity 🔬
@KirillLyapichev @sanamloghavi
#hemepath #hemepathMDA #PathTwitter
Characteristically prominent nuclear invaginations imparting a “cup-like” or “fish-mouth” morphology, with very strong MPO positivity 🔬
@KirillLyapichev @sanamloghavi
#hemepath #hemepathMDA #PathTwitter
(2/5) Cytoplasmic staining of NPM1 protein by IHC is predictive of NPM1 mutations
#hemepath #hemepathMDA #PathTwitter
#hemepath #hemepathMDA #PathTwitter
(3/5) This is because NPM1 mutations cause loss of the nucleolar localization signal and addition of a nuclear export signal, leading to increased protein export from
the nucleus and aberrant accumulation in the cytoplasm
#hemepath #hemepathMDA #PathTwitter
the nucleus and aberrant accumulation in the cytoplasm
#hemepath #hemepathMDA #PathTwitter
One of the many pearls that I learned from @ljmedeirosMD is:"The best time to learn, is after you know the diagnosis of a case, by going back to the slides and reading more about it".In this spirit, below are the answers of today's cases, with pictures #hemepath @KirillLyapichev
Case 1 : Marginal zone lymphoma
#hemepath #hemepathMDA #virtualhemepathMDA #virtualhemepath #virtualpath
#hemepath #hemepathMDA #virtualhemepathMDA #virtualhemepath #virtualpath
Case 2 : Diffuse large B-cell lymphoma, NGCB (with a T-cell rich background)
#hemepath #hemepathMDA #virtualhemepathMDA #virtualhemepath #virtualpath
#hemepath #hemepathMDA #virtualhemepathMDA #virtualhemepath #virtualpath
