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The chromosome 1q21 story (1/10):
-Having extra copies of generally odd num. chromosomes constituents hyperdiploidy #mmsm , recognized as ‘HY’ in GEP based molecular classification.
-Having 3 copies is called ‘gain 1q21’
-Having >=4 copies is called ‘amplification of 1q21’.
-Having extra copies of generally odd num. chromosomes constituents hyperdiploidy #mmsm , recognized as ‘HY’ in GEP based molecular classification.
-Having 3 copies is called ‘gain 1q21’
-Having >=4 copies is called ‘amplification of 1q21’.
The chromosome 1q21 story (2/10):
-Herve Avet-Louiseau identifies 1q21 ‘enhancement’ in human MM cell lines, primary MM cells and plasma cell leukemia (PMID: 9172003), Shaughnessy et al corroborate (PMID: 15472896).
- Gain/Amp ch. 1q21 first recognized as poor prognostic markers
-Herve Avet-Louiseau identifies 1q21 ‘enhancement’ in human MM cell lines, primary MM cells and plasma cell leukemia (PMID: 9172003), Shaughnessy et al corroborate (PMID: 15472896).
- Gain/Amp ch. 1q21 first recognized as poor prognostic markers
The chromosome 1q21 story (3/10):
...in MM by Arkansas group in mid-2000s (PMID: 16188652, PMID: 16705089)
- Corroborated by other groups (PMID: 16995883, PMID: 17024118, PMID: 20537706, PMID: 21523726) in the context of pre-novel and doublet novel induction/transplant era.
...in MM by Arkansas group in mid-2000s (PMID: 16188652, PMID: 16705089)
- Corroborated by other groups (PMID: 16995883, PMID: 17024118, PMID: 20537706, PMID: 21523726) in the context of pre-novel and doublet novel induction/transplant era.
