Discover and read the best of Twitter Threads about #histoplasmosis

Most recents (3)

immune reconstitution inflammatory syndrome #IRIS exaggerated atypical inflammatory response following initiation of ART either paradoxical worsening or unmasking of a infection
#IRIS memory T cells are redistributed from lymphoid tissue to organs, and the number of CD4+ and CD8+ T cells increases faster than that of regulatory T cells, resulting in an imbalance in the immune system
#Histoplasmosis-associated #IRIS rare with an estimated incidence rate of 0.74 cases per 1000 HIV-infected person-years and may present months after initiation of ART
Read 8 tweets
70M with swollen R 5th digit, hand and forearm. No fever / chills.

MRI: complex multi-compartment fluid collection with extensive flexor and extensor tenosynovitis

Debridement. Culture (photo).

What is your diagnosis and Rx?
#MayoIDQ MCQ to follow... Image
Elderly man with swollen right hand and forearm. MRI: complex fluid collection, extensive tenosynovitis. Debridement performed. Culture is shown (photo prior tweet).

Which of the following is the exposure associated with this infection?
3/
Beaver dam and blastomyces

When #IDBR says #beaverdam - you think #BLASTOMYCOSIS

nejm.org/doi/10.1056/NE…
Read 9 tweets
1/
What happens after you inhale Histoplasma into your lungs? Is #histoplasmosis always a deadly disease?

Here’s a #tweetorial or #pathtweetorial

You are at risk if you live in the Ohio or Mississippi River valleys, go spelunking, or work with chicken coops
2/
Many (maybe most) people who inhale Histoplasma remain asymptomatic. Many have symptoms that mimic “the flu” and are treated as such. Only a minority of immunocompetent folks are seriously and acutely ill at first exposure. This is called acute pulmonary histoplasmosis.
3/
What do you think happens next in the vast majority of infected individuals?
Read 31 tweets

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